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  • 1
    Electronic Resource
    Electronic Resource
    Expression of Neurotensin Messenger RNA in a Human Pancreatic Carcinoid Tumor (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 668 (1992), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1992.tb27370.x
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  • 2
    Electronic Resource
    Electronic Resource
    Ceruloplasmin and Deferoxamine Prevent Ischemia-Reperfusion Damage in Kidney Transplantation (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 723 (1994), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1994.tb36758.x
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  • 3
    Electronic Resource
    Electronic Resource
    Response of Isolated Bullfrog Gastric Mucosa to a Gastrin-like Pentapeptide (1967)
    [s.l.] : Nature Publishing Group
    Nature 214 (1967), S. 595-596 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Since acid secretion in the intact organism is regulated by distant, as well as local, nervous and hormonal influences, it was desirable to investigate the action of gastrin and its synthetic analogues on isolated tissue. In aprevious communication6 we reported the action of pure porcine gastrin on ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/214595a0
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  • 4
    Electronic Resource
    Electronic Resource
    Nerve Growth Factor as a Mitogen for a Pancreatic Carcinoid Cell Line (1995)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 64 (1995), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Carcinoid tumors are a group of neuroendocrine neoplasms distributed widely throughout the body but most commonly occurring in the gut. These tumors retain many characteristics of their neural crest origin, including secretion of neuroactive peptides and responsiveness to neurotrophic substances. Nerve growth factor (NGF), a neurotrophic protein involved in maintenance and differentiation of peripheral sympathetic and sensory neurons, regulates growth of several neural tumor cells by inducing a differentiated phenotype and subsequent inhibition of cell growth rate. We examined the actions of NGF in a functioning human pancreatic carcinoid cell line (termed BON). NGF has no effect on the cytoarchitecture or constitutive secretion of bioamines in this carcinoid cell line. NGF, however, stimulates the in vitro cellular proliferation of BON cells. BON cells possess mRNA for the NGF receptors (p75LNGFR and p140trkA) and membrane-associated tyrosine kinase activity is increased in response to NGF. Both the mitogenic activity of NGF, as well as the receptor-linked tyrosine kinase activity, can be abrogated in BON cells by the trkA inhibitor K-252a and specific anti-NGF antibody. Our studies demonstrate that NGF is a mitogen for this carcinoid cell line without effect on cellular phenotype or cytoarchitecture. NGF may play a role in the development and progression of human carcinoid tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1995.64062622.x
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  • 5
    Electronic Resource
    Electronic Resource
    The Human Carcinoid Cell Line, BON (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 733 (1994), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1994.tb17289.x
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  • 6
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    Unknown
    LAUREN (ed.), "The China Hands' Legacy: Ethics and Diplomacy" (Book Review) (1988)
    Ann Arbor, Mich., etc., : Periodicals Archive Online (PAO)
    Journal of Asian Studies. 47:1 (1988:Feb.) 122 
    Details
    ISSN: 0021-9118
    Topics: Political Science , Economics
    Description / Table of Contents: China and Inner Asia
    Notes: Book Reviews
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:1113-1988-047-01-000028
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  • 7
    Electronic Resource
    Electronic Resource
    The effect of glucagon on pancreatic secretion and plasma secretin in dogs (1977)
    Springer
    World journal of surgery 1 (1977), S. 93-97 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Quatre chiens porteurs de gastrostomie, de fistule pancréatique chronique et soumis a l'action de la sécrétine endogène, furent utilisés pour étudier l'action inhibitrice du glucagon sur la sécrétion exocrine du pancréas. Une infusion intraveineuse continue de glucagon (30 mg/kg-hre) fut maintenue pendant une heure après avoir établi un taux constant de sécrétion pancréatique par perfusion intra-duodénale d'acide hydrochlorique (9 mEq/hre). En comparaison avec les résultats obtenus dans une étude contrÔle dans laquelle les chiens furent soumis uniquement à la perfusion intraduodénale de HCl, l'infusion intraveineuse de glucagon s'accompagna d'une diminution significative du volume et de la concentration en bicarbonate des sécrétions pancréatiques. Par ailleurs le glucagon fut sans effet sur la concentration en protéine des sécrétions pancréatiques et sur les niveaux sanguins de sécrétine endogène. Les auteurs concluent que l'action inhibitrice du glucagon sur la sécrétion exocrine du pancréas ne se fait pas par inhibition de la mise en circulation de sécrétine. La ressemblance chimique entre le glucagon et la sécrétine suggère que le glucagon agit par compétition inhibitrice avec la sécrétine au niveau des récepteurs pancréatiques.
    Notes: Abstract The inhibitory effect of glucagon on pancreatic exocrine secretion induced by endogenously released secretin was studied in 4 dogs with chronic pancreatic fistulas and open gastric fistulas. After a constant level of pancreatic secretion was established by intraduodenal hydrochloric acid perfusion (9 mEq/hr), glucagon (30Μg/kg-hr) was administered intravenously for 1 hr. Compared to a separate control study in which dogs received intraduodenal HCl alone, glucagon caused a significant decrease in both pancreatic volume flow and bicarbonate output. Glucagon had no effect on pancreatic protein secretion, and circulating levels of endogenously released secretin remained unchanged. It is concluded that the inhibitory effect of glucagon on pancreatic secretion is not mediated through inhibition of secretin release. The chemical homology between glucagon and secretin suggests that glucagon may mediate its inhibitory action by competing with secretin at the level of the pancreatic receptor site.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01654742
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  • 8
    Electronic Resource
    Electronic Resource
    Invited commentary (1978)
    Springer
    World journal of surgery 2 (1978), S. 532-532 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01563695
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  • 9
    Electronic Resource
    Electronic Resource
    Radioimmunoassay of gastrointestinal hormones (1979)
    Springer
    World journal of surgery 3 (1979), S. 423-431 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Depuis 1968, des techniques de dosage radio-immunologique ont été mises au point pour les principales hormones gastro-intestinales (gastrine, cholécystokinine, sécrétine et GIP) et pour plusieurs substances dont la nature hormonale n'est pas encore tout à fait démontrée (VIP, motiline, polypeptide pancréatique, entéroglucagon, sérotonine, prostaglandines, entre autres). Les résultats rapportés par divers laboratoires sont assez concordants pour les taux sanguins de gastrine et de GIP, mais très discordants pour la sécrétine et la cholécystokinine. Pour les réponses qualitatives de ces hormones à divers stimuli, les résultats de divers laboratoires sont assez concordants. Une revue des travaux consacrés aux techniques de dosage radio-immunologique montre quels sont les problèmes techniques que l'on peut rencontrer.
    Notes: Abstract Since 1968, radioimmunoassays have been developed for major gastrointestinal hormones (gastrin, cholecystokinin, secretin, and gastric inhibitory peptide) and for many substances in the gastrointestinal tract that await full hormonal status (vasoactive intestinal peptide, motilin, pancreatic polypeptide, enteroglucagon, serotonin, prostaglandins, inter alia). Although reports between laboratories on the circulating levels of gastrin and gastric inhibitory polypeptide are in relatively good agreement, wide discrepancies exist in reported values of secretin and cholecystokinin. Reports on qualitative responses of these hormones to various stimuli, however, appear to be consistent between laboratories. A review of some of the studies of radioimmunoassay techniques for gastrointestinal hormones permits analysis of some of the technical problems that can be encountered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01556101
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  • 10
    Electronic Resource
    Electronic Resource
    Invited commentary (1977)
    Springer
    World journal of surgery 1 (1977), S. 229-229 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01665090
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