ISSN:
1573-2592
Keywords:
Biotin
;
prostaglandin
;
carboxylase
;
immunoregulatory dysfunction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The immunoregulatory system has recently been shown to require prostaglandins (PG) for its activation in man. We report here an impairment of immunoregulatory function, due to defective PGE monocytic production, in a 12-month-old boy with multiple carboxylase deficiency (MCD). The abnormal immune response was correctedin vitro by adding PGE to the medium. Moreover, PGE deficiency and immunoregulatory dysfunction responded to biotin administrationin vivo. It is suggested that the PGE deficiency in MCD could result from an impaired activity of a biotin enzyme, acetyl CoA carboxylase, since the product of this enzyme reaction, malonyl CoA, is required for prostaglandin synthesis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00915976
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