ISSN:
0942-0940
Keywords:
Antifibrinolytic therapy
;
cerebrospinal fluid
;
fibrin/fibrinogen degradation products
;
subarachnoid haemorrhage
;
tranexamic acid (AMCA)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Six patients with recently ruptured intracranial aneurysms were treated preoperatively with tranexamic acid (AMCA). Two patients received 6 g daily in i.v. infusion, two had 6 g daily by i.v. injection, and two patients were given AMCA 9 g daily by mouth during the first week after bleeding. Serial assays of AMCA and fibrin/fibrinogen degradation products (FDP) in cerebrospinal fluid (CSF) were performed during 6–13 days after the initial subarachnoid haemorrhage (SAH). Judged from the decline in CSF-FDP, an assumed therapeutic level of ≥ 1 mg/l of AMCA in CSF was reached within 24–36 hours after the first dose when the drug was administered intravenously and within 48 hours when the drug was given orally.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01401679
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