ISSN:
1569-8041
Schlagwort(e):
chemotherapy
;
children
;
Hodgkin's disease
;
late effects
;
secondary tumors
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract Background: To minimize the side effects of treatment in childrenwith Hodgkin's disease (HD), chemotherapy was given without radiotherapy. Patients and methods: From 1975 to 1984, 21 patients with HD havinglymph nodes 〈 4 cm were treated with six MOPP courses. From 1984 to 1987,all children presenting with HD (n = 17) were given six ABVD courses.From 1987 to 1993 all children (n = 21) were treated with sixalternating ABVD and MOPP courses. Results: MOPP-treated children showed an event-free survival (EFS)of 91%, overall survival, 100%; ABVD-treated children had an EFSof 70%, overall survival, 94%; ABVD-MOPP-treated children hadan EFS of 91% and an overall survival of 91%. Two casesdeveloped a second malignancy. Toxicity was low. Conclusions: In children, ABVD-MOPP treatment gives a good survival,and toxicity is low. Radiotherapy is not needed to treat HD in children.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1023/A:1008229211885
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