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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of intravenous omeprazole in children (1994)
    Springer
    European journal of clinical pharmacology 47 (1994), S. 181-185 
    Details
    ISSN: 1432-1041
    Keywords: Omeprazole ; pharmacokinetics ; children ; genetic polymorphism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract This study was undertaken to define the pharmacokinetics of omeprazole in children and included 13 patients, heterogenous in terms of age (0.3 to 19 years), underlying disease and biological constants, indication of omeprazole administration and associated therapy. The dose administered ranged from 36.9 to 139 mg·1.73 m−2. The pharmacokinetic parameters of omeprazole were: systemic clearance, 0.23 1·kg−1·h−1; volume of distribution, 0.45 1·kg−1; elimination half life 0.86 h; but were highly variable between individuals. Dosage, differences in hepatic and renal function and associated therapy may contribute to inter-individual variability. Within the range of doses administered, the pharmacokinetic parameters were similar to those reported in adults. The drug has been well tolerated in all children.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00194970
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of Meal and Intravenous Erythromycin on Manometric and Electrogastrographic Measurements of Gastric Motor and Electrical Activity (2000)
    Springer
    Digestive diseases and sciences 45 (2000), S. 525-528 
    Details
    ISSN: 1573-2568
    Keywords: electrogastrography ; erythromycin ; manometry ; children
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Electrogastrography (EGG) measures, on the skin surface, the myoelectrical activity attributable to gastric smooth muscle cells. The physiological significance of signal amplitude and variation has not been clearly established. The increased signal amplitude after eating a meal may be related to increased contractile activity or to gastric distension. This study investigates the effect of increased gastric motor activity, unaccompanied by gastric distension, on the EGG recording and compares it to the effect of a meal. Nine children (3 months to 15 years old), were assessed by antroduodenal manometry for chronic intestinal pseudoobstruction (N = 5), chronic vomiting (N = 2), and abdominal distension (N = 2). Synchronized EGG recording was performed simultaneously. During the study, four children were given a meal and five were given intravenous erythromycin 3 mg/kg over 1 hr. The ratio of the antral motor index (MI = number of waves × sum of amplitudes) determined 1 hr before a meal (or erythromycin) to that determined 1 hr after a meal (or during intravenous erythromycin) was calculated. The ratio of the running total spectrum power of the electrical signal at the same times was also calculated. Antral MI increased after a meal [MI ratio (mean ± se) 5.33 ± 2.2] and after intravenous erythromycin (MI ratio: 9.36 ± 2.6). The amplitude of the electrical activity also increased after the meal [power ratio (mean ± se) 3.01 ± 0.65] and after intravenous erythromycin (power ratio: 1.23 ± 0.39), but the increase was greater after the meal (P 〈 0.05 vs intravenous erythromycin). No correlation was found between antral MI ratio and running total spectrum power ratio. In conclusion, the increased amplitude of the gastric electrical activity recorded by the EGG after a meal seems to be only partly due to the increase in antral motor activity. The increase in power is also related to gastric distension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005445207628
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    Paper (German National Licenses)
    Fulltext
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