ISSN:
1432-1041
Keywords:
spironolactone
;
thiazides
;
digitalis
;
congestive heart failure
;
arterial hypertension
;
skeletal muscle potassium
;
serum potassium
;
skeletal muscle magnesium
;
serum magnesium
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The effect of adding spironolactone (Aldactone) on muscle electrolytes was studied in 48 patients with arterial hypertension and/or congestive heart failure who had received conventional diuretic treatment, including a potassium supplement, for more than 1 year. After 6 months on spironolactone 100 mg/day as well as the original conventional diuretic therapy, there was a significant increase in both skeletal muscle potassium and magnesium. At the same time these parameters decreased in the control group. In the spironolactone group there was also a significant increase in the mean serum potassium and creatinine levels. There was a significant fall in blood pressure in the spironolactone-treated group.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00542411
Permalink
