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  • 1
    Electronic Resource
    Electronic Resource
    Effects of spironolactone on serum and muscle electrolytes in patients on long-term diuretic therapy for congestive heart failure and/or arterial hypertension (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 535-540 
    Details
    ISSN: 1432-1041
    Keywords: spironolactone ; thiazides ; digitalis ; congestive heart failure ; arterial hypertension ; skeletal muscle potassium ; serum potassium ; skeletal muscle magnesium ; serum magnesium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of adding spironolactone (Aldactone) on muscle electrolytes was studied in 48 patients with arterial hypertension and/or congestive heart failure who had received conventional diuretic treatment, including a potassium supplement, for more than 1 year. After 6 months on spironolactone 100 mg/day as well as the original conventional diuretic therapy, there was a significant increase in both skeletal muscle potassium and magnesium. At the same time these parameters decreased in the control group. In the spironolactone group there was also a significant increase in the mean serum potassium and creatinine levels. There was a significant fall in blood pressure in the spironolactone-treated group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542411
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of triameterene on serum and skeletal muscle electrolytes in diuretic-treated patients (1988)
    Springer
    European journal of clinical pharmacology 33 (1988), S. 577-579 
    Details
    ISSN: 1432-1041
    Keywords: diuretics ; triamterene ; magnesium ; potassium ; plasma ; skeletal muscle ; hydrochlorothiazide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects on plasma and skeletal muscle electrolytes of the combination of triamterene 37.5 mg and hydrochlorothiazide 25 mg daily were studied in 19 patients on prior long-term (〉1 year) diuretic therapy for arterial hypertension and/or congestive heart failure. A further 20 patients fulfilling the same admission criteria were used as controls. Blood samples and skeletal muscle biopsies were taken before the study and after 6 months on therapy. The diuretic-treated group had a significant increase in skeletal muscle potassium and magnesium after 6 months on therapy as compared to the controls. Thus, the combination of triameterene and hydrochlorothiazide appeared effective in preserving the cellular content of potassium and magnesium on a long-term basis in the type of patient studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542490
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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