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  • 1
    Electronic Resource
    Electronic Resource
    No evidence for a protracted change in endogenous opioid activity following chronic opiate treatment in mice: parallel recovery of cross tolerance to stress and morphine antinociception (1984)
    Springer
    Psychopharmacology 82 (1984), S. 378-381 
    Details
    ISSN: 1432-2072
    Keywords: Opiate ; Withdrawal ; Stress ; Morphine ; Methadone ; Endorphins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The involvement of central endogenous opioids in swim-induced antinociception in mice is well documented. The response is attenuated by central or systemic naloxone, displays two-way cross tolerance with morphine and is correlated with apparent occupation of central opiate receptors by endogenous ligands. Swim-induced antinociception was utilised as an in vivo model of endogenous opioid function to investigate a possible protracted functional change in endogenous opioid release or inactivation following chronic opiate treatment. Antinociceptive responses (tailflick latency) to morphine (4.4 mg/kg, SC) and swimming were determined at various times following chronic methadone (24 days treatment, 102 mg/kg day in drinking water for the last 20 days) and chronic morphine (1 g/kg sustained release) treatment. In both experiments, parallel recovery from cross tolerance was observed for morphine-and swim-induced antinociception. These results were consistent with the view that no protracted functional change in the release or inactivation of endogenous opioids had occurred following chronic opiate treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427689
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Health-related quality of life in Australian children with asthma: lessons for the cross-cultural use of quality of life instruments (1998)
    Springer
    Quality of life research 7 (1998), S. 409-419 
    Details
    ISSN: 1573-2649
    Keywords: Asthma; ; children; ; quality of life; ; questionnaires; ; cross-cultural research.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The development of Australian forms of the Childhood Asthma Questionnaires (CAQs) is reported. Focus group methods and psychometric analyses were used to establish the conceptual, semantic and technical equivalence of these forms with the UK versions. Both versions also provide for data collection from non-asthmatic youngsters. The internal consistency was found to be acceptable (Cronbach's α 0.52–0.90) and the health-related quality of life (HRQoL) scores were found to vary with asthma severity (p〈0.05). Comparison with the UK data revealed that the non-asthmatic scores were higher for Australian than British children (p〈0.001) but that the scores for children with asthma did not differ between the two countries. It was only in the Australian sample that the group with asthma reported impaired HRQoL when compared to their healthy peers. These findings were interpreted in the context of cultural expectations of life quality and conclusions are presented regarding the importance of the gap between experience and expectations. The difficulties raised by the developmental and cultural issues inherent in paediatric HRQoL research were discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008805903785
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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