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Digitale Medien

Comparison of paracetamol metabolism in young adult and elderly males (1988)

Miners, J. O. ; Penhall, R. ; Robson, R. A. ; [weitere]

Springer

European journal of clinical pharmacology 35 (1988), S. 157-160

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Details

ISSN: 1432-1041

Schlagwort(e): paracetamol ; drug metabolism ; age ; sulphation ; glucuronidation

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary Paracetamol metabolism was compared in groups of young adult (mean age 20.8 years) and elderly (mean 79.3 years) males. Apparent oral clearance and half-life and partial metabolic clearances to the glucuronide and glutathione-derived conjugates of paracetamol were not significantly different between the two groups. However, the partial metabolic clearance to paracetamol sulphate was 23.1% lower and renal clearance of unchanged drug was 42.9% lower in the elderly compared to the young adults. Despite the decreased clearance by these pathways, reduction in paracetamol dosage should not be necessary in the elderly.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00609245

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