ISSN:
1432-1041
Keywords:
paracetamol
;
drug metabolism
;
age
;
sulphation
;
glucuronidation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Paracetamol metabolism was compared in groups of young adult (mean age 20.8 years) and elderly (mean 79.3 years) males. Apparent oral clearance and half-life and partial metabolic clearances to the glucuronide and glutathione-derived conjugates of paracetamol were not significantly different between the two groups. However, the partial metabolic clearance to paracetamol sulphate was 23.1% lower and renal clearance of unchanged drug was 42.9% lower in the elderly compared to the young adults. Despite the decreased clearance by these pathways, reduction in paracetamol dosage should not be necessary in the elderly.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00609245
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