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  • dipotassiumchlorazepate  (1)
  • enteric-coated tablets  (1)
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  • 1
    Digitale Medien
    Digitale Medien
    On the pharmacokinetics of proscillaridin A in man (1975)
    Springer
    European journal of clinical pharmacology 8 (1975), S. 421-425 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Proscillaridin ; enteric-coated tablets ; plasma levels ; urine excretion ; 86Rb-erythrocyte assay ; man
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The plasma concentration of proscillaridin was measured by a modified86Rd method during treatment with multiple doses of a commercial preparation of proscillaridin. Despite high doses, very low plasma levels were found, and there were only minute amounts of glycoside activity in urine and faeces. Administration of an enteric-coated proscillaridin preparation gave higher plasma levels, which raises the possibility of inactivation of the glycoside by acid gastric juice. The results suggest that proscillaridin has low biological availability when given orally, and that it is extensively metabolised in the body.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00562316
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
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  • 2
    Digitale Medien
    Digitale Medien
    Intramuscular bioavailability of chlorazepate as compared to diazepam (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 229-230 
    Details
    ISSN: 1432-1041
    Schlagwort(e): diazepam ; dipotassiumchlorazepate ; benzodiazepines ; bioavailability ; administration ; healthy volunteers
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Dipotassium chlorazepate (DPC) and diazepam (DZM) were given i.m. and i.v. to 6 healthy volunteers in doses of 20 mg (48.9 µmol) DPC and 15 mg (52.0 µmol) DZM. The interval between the injections was at least 1 week. Plasma samples were analyzed for DPC and DZM by HPLC. The bioavailability of DPC and DZM after i.m. administration, determined from computer calculated AUCs, was 1.04 and 0.85, respectively.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00609698
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
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