ISSN:
1573-5168
Keywords:
estrogen receptor
;
estradiol
;
gonadotropin-releasing hormone
;
tyrosine hydroxylase
;
gonadotropin
;
hypothalamus
;
pituitary
;
neuroendocrine control of reproduction
;
salmonid
;
teleost fish
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract In all vertebrates, steroid feedback is one of the mechanisms by which the brain is constantly kept informed on the physiological status of the periphery. It is, therefore, a very efficient system of synchronization between the different actors of the brain-pituitary-effector axis, particularly in the context of reproduction. The central effects of steroids are mediated by specific receptors belonging to the superfamily of intracellular receptors and acting as ligand dependant transcription factors to modulate the expression of certain target genes. In order to investigate the molecular events underlying steroid actions in the brain/pituitary complex, it is necessary, as a first step, to locate precisely steroid expressing cells in the brain/pituitary complex and to identify the phenotype of these cells on the basis of the neurohormone(s) or hormones they produce. This paper will review recent data obtained in our laboratory regarding the distribution and regulation of expression of estrogen receptors in the brain and pituitary gland of the rainbow trout (Oncorhynchus mykiss), using both in situ hybridization or immunohistochemistry. In addition, information concerning the phenotypic identification of cells expressing these receptors is presented, especially with respect to the main neuroendocrine systems controlling reproduction. The functional meaning of these data are discussed in the context of the reproductive physiology of trout.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1007749715473
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