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Digitale Medien

Failure of opioids to affect excitation and contraction in isolated ventricular heart muscle (1989)

Nawrath, H. ; Rupp, J. ; Jakob, H. ; [weitere]

Springer

Cellular and molecular life sciences 45 (1989), S. 337-339

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Details

ISSN: 1420-9071

Schlagwort(e): Heart muscle ; opioids ; morphine ; ethylketocyclazocine ; cardiac function ; presynaptic modification

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Summary The opioid agonists morphine (selective for μ-receptors) and ethylketocyclazocine (selective for kappa-receptors), at concentrations evoking strong effects in neuronal structures, did not significantly affect the configuration of the intracellularly recorded action potential and the force of contraction in ventricular heart muscle isolated from guinea pigs, rabbits and man. These results suggest that any changes of heart functions in vivo in response to opioid-like drugs are probably not mediated postsynaptically at the myocardial cell membrane but rather presynaptically, influencing the release of noradrenaline and/or acetylcholine from the nerve terminals.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01957469

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