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  • 1
    Electronic Resource
    Electronic Resource
    Response of gastric inhibitory polypeptide (GIP) to oral administration of nutrients in normal and pancreatectomized dogs
    Amsterdam : Elsevier
    Regulatory Peptides 5 (1983), S. 263-272 
    Details
    ISSN: 0167-0115
    Keywords: arginine ; fat ; glucagon ; glucose ; insulin
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-0115(83)90257-4
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of glicentin-related peptides on glucagon secretion in anaesthetized dogs (1986)
    Springer
    Diabetologia 29 (1986), S. 397-401 
    Details
    ISSN: 1432-0428
    Keywords: GLI ; glicentin-related peptide ; glucagon ; insulin ; dog pancreas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recent studies have demonstrated that glicentin is released during nutrient ingestion. However, the biological function of glicentin remains unclear. In order to clarify the role of glicentin in the enteroinsular axis, the effect of glicentin-related peptides was investigated using in vivo local circulation of canine pancreas. Peaks I and II of gut glucagon-like immunoreactivity, partially purified from porcine intestinal extract by affinity chromatography and gel filtration, synthesized hexadecapeptide of N-terminal glicentin (1–16) and synthesized octapeptide of C-terminal glicentin (62–69) were administered for 10 min into the pancreaticoduodenal artery of canine pancreas. Blood samples were then drawn from the pancreaticoduodenal vein. The administration of peak I of glucagon-like immunoreactivity during arginine infusion in a dosage of 20 ng reduced the glucagon secretion by 42 pmol/1 (p〈0.05), whereas peak 11 of glucagon-like immunoreactivity (20 ng) slightly increased the plasma level of insulin, although not significantly. The administration of glicentin (1–16) in a dosage of 400 ng during saline infusion did not alter the plasma insulin level, but reduced the plasma glucagon level in the pancreaticoduodenal vein by 29 pmol/1 (p〈0.05). In addition, glicentin [62–691 in a dosage of 400 ng exerted a decrease in both the plasma insulin (40 mU/1,p〈0.05) and glucagon level (27 pmol/l,p〈0.05). The present study demonstrates the suppression of pancreatic glucagon release during the infusion of peak I glucagon-like immunoreactivity and N- or C-terminal glicentin-related peptide. Therefore, it is suggested that glicentin released during nutrient intake might inhibit the secretion of glucagon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00903352
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  • 3
    Electronic Resource
    Electronic Resource
    Insulin and glucagon in spontaneously diabetic non-obese mice (1984)
    Springer
    Diabetologia 27 (1984), S. 460-463 
    Details
    ISSN: 1432-0428
    Keywords: Non-obese diabetic mice ; pancreas ; stomach ; insulin ; glucagon ; intestine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To investigate the rôle of glucagon in the development of diabetes mellitus, spontaneously diabetic non-obese mice were studied before (group 1) and after the onset of diabetes mellitus (group 2). In group 1, fasting blood glucose and insulin in plasma and pancreas did not differ significantly, while plasma glucagon was elevated (48.9±10.4 versus control 18.6±6.0pmol/l). In group 2, the insulin content of plasma and the pancreas were markedly reduced, whereas plasma glucagon was elevated (180.9±59.1 pmol/l). When diabetic mice were treated with insulin for 4 weeks (group 3), plasma glucagon was markedly reduced compared with that of group 2 (30.3±9.0 pmol/l). In group 1, glucagon and glucagon-like immunoreactivity of the intestine were reduced. The glucagon content of the intestine was elevated in group 2. Group 3 elicited increased contents of gastric glucagon as well as intestinal glucagon-like immunoreactivity. We conclude that, in addition to insulin deficiency, hypersecretion of glucagon might contribute to the development and clinical course of diabetes mellitus in the non-obese diabetic mouse.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00273911
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  • 4
    Electronic Resource
    Electronic Resource
    Fracture studies in rubber-modified acrylics. I. Experimental method: Design of sandwich-tapered double-cantilever beam cleavage specimens (1973)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 17 (1973), S. 1909-1917 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Double-cantilever beam cleavage specimens are very useful in characterizing the fracture behavior of isotropic, homogeneous, brittle, and semibrittle polymers. However, until this time they have not been used for ductile materials such as rubber-modified polymers or polycarbonates because of excessive yielding or breakage of the specimen arms before crack propagation can occur. In order to make it possible to measure the fracture surface work of these materials, a new sandwich cleavage specimen was developed by bonding rigid reinforcement plates to both sides of the specimen sheet. With this sandwich-tapered double-cantilever beam cleavage specimen, one can create conditions under which controlled crack propagation through tough ductile materials and measurement of the fracture surface work-two previously unobtainable results-are readily determined. In this paper, the design and construction of the sandwich specimens, test procedure, and the data analysis will be discussed in detail.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1973.070170623
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  • 5
    Electronic Resource
    Electronic Resource
    Fracture studies in rubber-modified polymers. II. Experimental results: Fracture surface work of rubber-modified acrylics (1973)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 17 (1973), S. 2053-2066 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: With the use of a sandwich-tapered double-cantilever beam cleavage specimen (described in part I of this series), the fracture surface work of several commercial and experimental acrylic multipolymers has been measured as a function of crack velocity and rubber content. The plots of fracture surface work versus crack velocity clearly exhibit the effects of rate (crack velocity) and rubber concentration on fracture behavior. Specifically, the fracture surface work of specimens with seven different rubber contents has been determined over a crack velocity range from 10-5 meters/sec to approximately 10 meters/sec. For each material, distinct maxima occur in the curves of fracture surface work versus crack velocity. The significance of these observations is discussed.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1973.070170708
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  • 6
    Electronic Resource
    Electronic Resource
    Osteogenic cell cytotoxicity and biomechanical strength of the new ceramic Diopside (1997)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 37 (1997), S. 100-107 
    Details
    ISSN: 0021-9304
    Keywords: Diopside ; biocompatibility ; osteogenic cell (MC3T3-E1) ; biomechanical strength ; apatite wollastonite-containing glass-ceramic (AWGC) ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Diopside was prepared by sintering a powder compact composed of CaMgSi2O6 at 1573K for 2 h. In order to clarify the biocompatibility of Diopside, the cytotoxicity of Diopside against the osteogenic cell line MC3T3-E1 and the bone-Diopside interface strength were examined. On both the 14th and 21st days of incubation of MC3T3-E1 cells with Diopside, ALP activities were not significantly lower than those of the CTRL. TEM photographs of MC3T3-E1 on Diopside after 14 days of incubation showed active secretion of crystals from osteoblast-like cells. Scanning electron microscopic analysis showed that the cells on Diopside formed multiple cell layers similar to those on the CTRL both 14 and 21 days after incubation. These results showed that Diopside had no cytotoxic effect on MC3T3-E1. The pulling test showed that failure loads of Diopside were significantly lower than those of AWGC. Histologically, there was no fibrous tissue or foreign body reaction at the bone interface. SEM-EPMA showed that Diopside had attached to the bone via a calcium-phosphorus layer. SEM back-scattered electron imaging showed that the Diopside plate had degraded to a porous state 12 weeks after implantation. These findings indicate that Diopside is a biodegradable ceramic. © 1997 John Wiley & Sons, Inc. J Biomed Mater Res, 37, 100-107, 1997.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 7
    Electronic Resource
    Electronic Resource
    Copolymerization of ketene and benzaldehyde (1967)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 105 (1967), S. 292-295 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1967.021050130
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  • 8
    Electronic Resource
    Electronic Resource
    A high temperature light scattering instrument and some results on polyethylene (1957)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Polymer Science 24 (1957), S. 156-160 
    Details
    ISSN: 0022-3832
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1957.1202410524
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