ISSN:
1573-6903
Keywords:
Tubulin
;
glial fibrillary acidic protein
;
gene expression
;
human fetal brain
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Developmental alterations in the expression of glial fibrillary acidic protein (GFAP) and α-tubulin were examined at the level of mRNA and protein in human fetal brain between weeks 13–23 of gestation. Except for a transient increase at week 15, GFAP expression in the cytoskeletal (CSK) fraction was low until week 17, when it increased steadily to week 23, corresponding to the phase of glial proliferation. The developmental profile of α-tubulin in the CSK fraction displayed a biphasic pattern, with an initial rise between weeks 13–16 coinciding with the early phase of neuroblast multiplication, and a second rise between weeks 17–23 corresponding to the phase of glial proliferation. No significant difference in the spatial distribution of α-tubulin was found in different region of brain but GFAP expression varied with a higher level in cerebellum than that in cerebrum at late midgestation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1021096224161
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