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  • islet-cell antibodies  (2)
  • HIDA 99mTc hepatobiliary scintigraphy  (1)
  • 1
    ISSN: 1432-0428
    Schlagwort(e): Insulin-dependent diabetes mellitus ; T and B lymphocytes ; islet-cell antibodies ; autoimmunity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The lymphocyte subpopulations of 26 insulin-dependent diabetics were studied. Thirteen of them had persistent pancreatic islet-cell serum antibodies (ICA) (mean (±SD) duration of diabetes 11 ± 8 years). The others were ICA-negative (mean duration of diabetes 10±8 years). The mean fasting blood glucose in the week before the lymphocyte count was 1.37±.45 g/1 (two specimens for every patient). As controls 19 healthy volunteers, sex and age matched, were investigated. The T-lymphocyte count was no different in diabetics compared to controls, B-cells were significantly raised (p 〈0.01) in the ICA-positive group, when tested with antihuman gammaglobulin sera (IgG + IgA + IgM), anti-human IgG and anti-human IgM, while no difference was observed between ICA-negative patients and normal subjects. IgA-bearing lymphocytes were equally raised in both diabetic groups (p 〈0.05). These data show an altered immunological balance in type IB (autoimmune) diabetes, characterized by an increased number of B-lymphocytes.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1432-0428
    Schlagwort(e): Insulin-dependent diabetes mellitus ; T and B lymphocytes ; islet-cell antibodies ; autoimmunity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The lymphocyte subpopulations of 26 insulin-dependent diabetics were studied. Thirteen of them had persistent pancreatic islet-cell serum antibodies (ICA) (mean (± SD) duration of diabetes 11 ±8 years). The others were ICA-negative (mean duration of diabetes 10±8 years). The mean fasting blood glucose in the week before the lymphocyte count was 1.37±0.45 g/l (two specimens for every patient). As controls 19 healthy volunteers, sex and age matched, were investigated. The T-lymphocyte count was no different in diabetics compared to controls, B-cells were significantly raised (p〈0.01) in the ICA-positive group, when tested with antihuman gammaglobulin sera (IgG + IgA + IgM), anti-human IgG and anti-human IgM, while no difference as observed between ICA-negative patients and normal subjects. IgA-bearing lymphocytes were equally raised in both diabetic groups (p〈0.05). These data show an altered immunological balance in type IB (autoimmune) diabetes, characterized by an increased number of B-lymphocytes.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 3
    Digitale Medien
    Digitale Medien
    Springer
    European journal of nuclear medicine 10 (1985), S. 549-550 
    ISSN: 1619-7089
    Schlagwort(e): Bile reflux ; HIDA 99mTc hepatobiliary scintigraphy ; Gastroesophageal reflux
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In 5 patients with partial gastric resection and esophagitis, in whom esophageal pH metry was unable to demonstrate significant gastroesophageal reflux (GER), we administered i.v. 5 mCi (185 MBq) of 99mTc-HIDA, the patient lying under a computer-assisted LFOV gamma camera. When gallbladder image was evident, caerulein was administered i.v. at a physiologic dose in order to induce gallbladder contraction, and in the subsequent 45 min the patient was asked to perform a standard series of manoeuvres that increase the intraabdominal pressure (Valsalva, etc.) and favour GER. Scintigraphic images and time/activity curves obtained from areas of interest corresponding to gastric remnant and distal esophagus showed that at least one of these manoeuvres in each case was followed by the appearance of the radiocompound in the distal esophagus, indicating a 99mTc-HIDA-tagged bile GER. Consequently, we believe that HIDA-GER dynamic scintigraphy may be more useful than esophageal pH metry in demonstrating the biliary origin of an esophagitis.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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