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  • 1
    Electronic Resource
    Electronic Resource
    Relation between serum levels of tissue polypeptide antigen (TPA) and cancer antigen 125 (CA125) and their immunohistochemical identification in benign and malignant gynecological disease (1988)
    Springer
    Archives of gynecology and obstetrics 243 (1988), S. 41-50 
    Details
    ISSN: 1432-0711
    Keywords: Tumor marker ; Immunohistochemical investigation ; Peroxidase anti-peroxidase method ; Avidin biotin immunoperoxidase technique ; Tumor specificity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We studied immunohistochemical stains for TPA and CA125 in patients with benign and malignant gynecologic diseases. The results were as follows: (1) CA125 was not found in ovarian mucinous cystadenocarcinoma but was demonstrated immunohistochemically in 82% of ovarian serous cystadenocarcinomas and 83% of Krukenberg's tumors. (2) TPA was demonstrated in 65% of ovarian serous and 75% of ovarian mucinous cystadenocarcinomas, and in 58% of endometrial carcinomas. (3) TPA was found in all trophoblastic tumors examined, while CA125 was found in none. Eighty-three percent of patients with trophoblastic diseases had raised serum TPA levels. (4) When serum CA125 levels were raised, CA125 was demonstrated immunohistochemically in 71% of patients with ovarian serous cystadenocarcinomas, 67% of patients with Krukenberg's tumors and 100% of patients with tubal carcinomas. (5) Despite elevated serum levels, CA125 and TPA were not identified by immunohistochemistry in 64% cases of benign ovarian disease and in 80% of patients with uterine myomata. (6) It would seem that CA125 was more easily released from tumor cells than TPA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00931550
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  • 2
    Electronic Resource
    Electronic Resource
    Serum levels of six tumor markers in patients with benign and malignant gynecological disease (1988)
    Springer
    Archives of gynecology and obstetrics 243 (1988), S. 61-68 
    Details
    ISSN: 1432-0711
    Keywords: Tumor marker ; Combination assay ; Early diagnosis ; Screening
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We studied the pretreatment serum levels of 6 tumor markers in gynecological patients with and without malignant disease. The tumor markers were carcinoembryonic antigen (CEA), tissue polypeptide antigen (TPA), ferritin, Schwangerschaftsprotein 1 (SP1), Schwangerschaftsprotein 3 (SP3) and cancer antigen 125 (CA125). The results were as follows: (1) Serum CA125 and TPA levels were raised in 81% and 57% of patients with ovarian serous cystadenocarcinoma: CEA and SP3, in 52% and 43% respectively of patients with ovarian mucinous cystadenocarcinoma; CA125, TPA and SP3, in 76%, 48% and 48% respectively of patients with other ovarian malignancies; and TPA and SP3, in 56% and 40% respectively of patients with endometrial carcinoma. (2) Serum levels of TPA, ferritin and CA125 were more often raised with advancing stages of malignant disease. (3) Serum TPA levels were elevated in 55% of patients with stage I endometrial carcinoma, and serum SP3 levels were elevated in 35% of patients with a stage I malignant ovarian neoplasm and in 45% of patients with endometrial carcinoma. (4) One of the 6 tumor markers showed a raised level in 84% of patients with gynecologic malignancy as against 56% in those with benign gynecologic diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00932971
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of dopamine and haloperidol on the c-wave and light peak of light-induced retinal responses in chick eye (1987)
    Springer
    Documenta ophthalmologica 65 (1987), S. 87-95 
    Details
    ISSN: 1573-2622
    Keywords: c-wave ; centrifugal fibers ; chick retina ; dopamine ; electroretinogram ; haloperidol ; light peak
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The relation between dopaminergic cells (and centrifugal fibers), the electroretinogram (ERG) c-wave, and the light peak were electrophysiologically investigated by observing the effects of a retrobulbar conduction block and intravitreal injection of either dopamine or haloperidol on these retinal responses. The retrobulbar conduction block (1% lidocaine) caused a decrease in the amplitude of the c-wave and the light peak in newly hatched chicks. Injections (2–20 μl) containing dopamine (0.1–10 mM) or haloperidol (1.3–13 mM) were given intravitreously while the responses were recorded. Although intravitreous injection of saline for control resulted in no observable change in the responses, dopamine selectively augmented the c-wave of ERGs and the light peak, but not the a-, b-, and d-waves. Haloperidol decreased first the light peak and later the c-wave. The augmentation of the retinal responses by dopamine and their reduction by haloperidol was statistically significant. The estimated threshold concentration of dopamine in the vitreous cavity was 1–3.5 μM. Since in many species the interplexiform cells have been found to contain dopamine, we hypothesize that the modulatory effects on the c-wave and the light peak in this preparation may be due to a centrifugal feed-back loop which includes the interplexiform cells to the horizontal and bipolar cells and the horizontal cells to the cones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00162724
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  • 4
    Electronic Resource
    Electronic Resource
    Gamma-aminobutyric acid- and picrotoxin-induced changes in c-wave and light peak of retinal potentials in the chick (1987)
    Springer
    Documenta ophthalmologica 65 (1987), S. 333-342 
    Details
    ISSN: 1573-2622
    Keywords: c-wave ; electroretinogram ; GABA ; light peak ; picrotoxin ; retinal standing potential
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Retinal potentials were recorded from the eyes of anesthetized and immobilized chicks by a standard direct current method. The amplitude of the electroretinogram (ERG) c-wave was measured 2 and 5 sec after the onset of the light stimulus, as indexes of the fast-rise c-wave (cF-wave) and the slow-rise c-wave (cs-wave), respectively. An intravitreal injection of gamma-aminobutyric acid (GABA) at an estimated intravitreal concentration of 10−9-10−7M resulted in an increase of the amplitude of the cs-wave, a less remarkable change in the a- and cF-waves, and a slight decrease in the b-wave. The light peak of the retinal standing potential increased in amplitude following GABA administration (10−7-10−4M). Following an intravitreal injection of picrotoxin (10−5-10−3M), the polarity of the cs-wave changed from positive to negative and a significant decrease and deformation in the light peak was observed. The amplitude of the a-wave, however, increased in the range of the higher dose, while that of the b- and cf-waves decreased markedly but no polarity reversal of the cF-wave was found. The results may suggest that the GABA-ergic synapse plays a significant role in production of the cs-wave and the light peak, along with that of the pigment epithelium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00149939
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    Paper (German National Licenses)
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