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  • 1
    Electronic Resource
    Electronic Resource
    Fenofibrate and colestipol: Effects on serum and lipoprotein lipids and apolipoproteins in familial hypercholesterolaemia (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 191-194 
    Details
    ISSN: 1432-1041
    Keywords: colestipol ; fenofibrate ; familial hypercholesterolaemia ; lipoproteins ; serum lipids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Effects on serum lipoproteins were studied in ten patients with familial hypercholesterolaemia (FH) during consecutive eight-week treatment periods with fenofibrate 0.3 g/day, fenofibrate plus colestipol, 15 g/day, and fenofibrate 0.25 g/day plus colestipol. VLDL, LDL, HDL, HDL2, and HDL3 were isolated by ultracentrifugation and precipitation. Lipids and apolipoproteins A–I and B were determined by enzymatic and immunonephelometric techniques, respectively. Administration of fenofibrate alone resulted in decreases in VLDL and LDL cholesterol (−48% and −18%) and in serum apolipoprotein B (−10%), but in increases in HDL, HDL2, and HDL3 (+25%, +26%, and +24%), and in serum apolipoprotein A–I (+6%). Addition of colestipol produced a further reduction in LDL cholesterol (−31%) and in serum apolipoprotein B (−19%). The effects were maintained with less fenofibrate. In FH, an acceptable therapy combines the favourable effects of sufficient lowering of LDL and of a rise in HDL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614301
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  • 2
    Electronic Resource
    Electronic Resource
    Short- and long-term effects of lovastatin and pravastatin alone and in combination with cholestyramine on serum lipids, lipoproteins and apolipoproteins in primary hypercholesterolaemia (1992)
    Springer
    European journal of clinical pharmacology 42 (1992), S. 353-358 
    Details
    ISSN: 1432-1041
    Keywords: Lovastatin ; Pravastatin ; Hypercholesterolaemia ; cholestyramine ; lipoproteins ; apolipoproteins ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of the HMG CoA reductase inhibitors lovastatin and pravastatin on serum lipids, lipoproteins and apolipoproteins have been studied in 35 patients with primary hypercholesterolaemia. LDL cholesterol was lowered to the same extent by both agents compared on a mg basis of each drug per day. HDL cholesterol was increased by lovastatin but not by pravastatin. The reduction in serum triglycerides, VLDL triglycerides and VLDL cholesterol was more pronounced after lovastatin than pravastatin. After 1 year the effect of combined treatment with 40 mg pravastatin and 8 g cholestyramine on the reduction in LDL cholesterol (−39%) in 13 patients was comparable to that of 80 mg lovastatin plus 8 g cholestyramine (−40%) in 12 patients with identical baseline values. Differences were also found in the effects of the combination therapy with the two drugs on HDL cholesterol, serum triglycerides, VLDL triglycerides, VLDL cholesterol, and apolipoproteins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00280117
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  • 3
    Electronic Resource
    Electronic Resource
    Untersuchungen über biologische Wirkungen eines lipolytisch wirksamen Peptids aus Schweinehypophysen (Fraktion H) (1969)
    Springer
    Clinical and experimental medicine 149 (1969), S. 226-232 
    Details
    ISSN: 1591-9528
    Keywords: Fraction H ; Pig pituitaries ; Immunologic properties ; Fraktion H ; Schweinehypophysen ; Immunologische Eigenschaften
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Mit Fraktion H ließ sich bei Kaninchen ein wirksames Antiserum (AFHS) erzeugen, das bereits in einer Menge von 0,05 ml 1000 μg Fraktion H vollständig absorbierte und die lipolytische Wirkung vollkommen aufhob. Der Antikörper (AK) im AFHS, der sich als IgG isolieren ließ, hatte in einer Konzentration von 0,08 mg den gleichen Effekt. Zwischen AFHS und den lipolytisch wirksamen Polypeptidhormonen ACTH, STH und α-MSH ließen sich keine Präcipitationslinien nachweisen. Während Fraktion H mit AFHS drei Präcipitationslinien ergab, zeigte sich bei der weiter gereinigten Fraktion J nur noch eine Präcipitationslinie mit APHS, die mit einer der drei Linien von Fraktion H das Bild der Vollidentität bot.
    Notes: Summary 0.05 ml of a potent antiserum (AFHS), we gained by immunisation of rabbits with fraction H from pig pituitaries, totally absorbed 1000 μg fraction H and completely blocked their lipolytic effect in vivo. The same could be achieved by the isolated antibody (IgG) in a concentration of 0.08 mg. There were no precipitation lines between AFHS and the polypeptides ACTH, STH and α-MSH. Instead of three lines between fraction H and APHS the purified fraction J gave only one precipitation line with APHS, which was identical with one of the lines of fraction H.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02044478
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  • 4
    Electronic Resource
    Electronic Resource
    In vivo-Untersuchungen beim Miniaturschwein mit einem lipidmobilisierenden Polypeptid aus Schweinehypophysen (1972)
    Springer
    Research in experimental medicine 158 (1972), S. 246-250 
    Details
    ISSN: 1433-8580
    Keywords: Lipidmobilizing peptide ; Pig pituitaries ; FFS ; Free glycerol ; Glucose ; Minipig ; Lipidmobilisierendes Peptid ; Schweinehypophysen ; FFS ; Freies Glycerin ; Glucose ; Miniaturschwein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An Hanford-Miniaturschweinen wurde die In vivo-Wirkung des von uns aus Schweinehypophysen gewonnenen lipidmobilisierenden Peptid A und seiner weniger gereinigten Vorstufe Fraktion J in einer Dosierung von 100 µg/kg i.v. untersucht: Peptid A (FFS-Anstieg um 2,13 ± 0,2 mval/l) war stärker wirksam als Fraktion J (1,25 ± 0,23 mval/l). Die lipolytische Wirkung war bereits 5 min nach Injektion nachweisbar. Beide Substanzen führten zwar zu einem signifikanten Blutzuckeranstieg; nach Peptid A-Gabe war jedoch 60 min nach Injektion ein zwischenzeitlicher Glucoseabfall unter Ausgangswerte festzustellen, der mit dem Maximum der FFS zusammenfiel.
    Notes: Summary The effect of pig pituitary lipidmobilizing Peptide A and its precursor fraction J was studied in Hanford minipigs. Within 5 min after the intravenous injection of 100 µ/kg of the polypeptides free fatty acids and free glycerol were elevated; the maxima were obtained 60 respectively 30 min p.i. Peptide A was more active than fraction J (2.13 ± 0.21 respectively 1.25 ± 0.23 mval/l FFS increment compared to the initial values). Glucose was significantly elevated 210 min after the injection of either peptide, but peptide A produced a decrease of glucose 60 min p.i. when FFS were maximal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01852315
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  • 5
    Electronic Resource
    Electronic Resource
    Darstellung eines lipolytisch wirksamen Polypeptids (Peptid A) aus Hypophysen vom Schwein (1971)
    Springer
    Clinical and experimental medicine 155 (1971), S. 195-203 
    Details
    ISSN: 1591-9528
    Keywords: Lipolytic peptide A ; Pig pituitary ; Isolation of peptides ; Lipolysis ; Immunoreactivity of pituitary peptide ; Peptid A ; Schweinehypophysen ; Isolierung ; Lipolyse ; Immunologie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Aus Hypophysen vom Schwein wurde eine als Peptid A bezeichnete Substanz dargestellt, die sich unter den angegebenen Bedingungen als einheitlich in Säulenchromatographie, Acetatfolien- und Acrylamidgelelektrophorese, Ultrazentrifuge sowie im Immunodiffusionstest erwies. Das mit der Ultrazentrifuge bestimmte Molekulargewicht lag bei 5700. Die minimal wirksame Dosis betrug bei Kaninchen in vitro 0,1 Μg/ml. Nach den vorliegenden Untersuchungen ist anzunehmen, daß Peptid A von MSH, ACTH, STH und TSH verschieden ist.
    Notes: Summary A substance called Peptide A was prepared from pig pituitaries. With the conditions used this substance proved to be homogeneous by column chromatography, acetate and acrylamide gel electrophoresis, ultracentrifugation as well as in the immuno diffusion test. By means of the ultracentrifuge a molecular weight of 5700 was determined. The minimum effective dose in rabbits was 0.1 Μg/ml in vitro. According to the information so far available it would seem that Peptide A differs from MSH, ACTH, STH and TSH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02047608
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