ISSN:
1432-0428
Keywords:
Insulitis
;
lymphocyte transfer
;
cellular immunity
;
streptozotocin
;
experimental diabetes mellitus
;
glucose intolerance
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We have tested whether experimental insulitis induced by multiple subdiabetogenic injections of streptozotocin can be transferred by lymphocytes to normal recipients. C57BL/6J mice were treated on 5 consecutive days with 40 mg streptozotocin /kg body weight. 5×107 nucleated spleen cells from 20 animals which had developed hyperglycaemia with concomitant insulitis three weeks after the first streptozotocin-injection, were transferred into congenic thymusless C57BL/6J-nu/nu mice. The cell transfer led to lymphocytic infiltrations of pancreatic islets in 75% of the recipients. Hyperglycaemia was not observed. It is concluded that lowdose streptozotocin treatment induces cellular immune reactions against pancreatic islets.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00253178
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