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  • 1
    Electronic Resource
    Electronic Resource
    Interleukin-6 (IL-6) production in carcinoma of the cervix (1996)
    Springer
    Archives of gynecology and obstetrics 258 (1996), S. 25-33 
    Details
    ISSN: 1432-0711
    Keywords: Interleukin-6 (IL-6) ; Carcinoma of the uterine cervix ; Histologic type ; Carcinogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Interleukin-6 (IL-6) is a pleiotropic cytokine that is not only a mediator in major immunologic reactions but also a growth factor of keratinocytes. We studied the IL-6 secretion in vitro of 15 human cell lines derived from both squamous cell carcinoma (SCC) and adenocarcinoma of the uterine cervix. Four of the eight well differentiated SCC secreted a large amount (〉 1500 pg/48 h/106 cells) of IL-6 in nude mice. In contrast, poorly differentiated SCC cell lines and all of the 7 adenocarcinoma cell lines secreted a small amount (〈 500 pg/48 h/106 cells of IL-6). The expression of IL-6 mRNA of the cell lines correlated well with their IL-6 secretion potential. However, the expression of IL-6 receptor did not correlate with the IL-6 secretory potential. We also studied the IL-6 secretion of freshly isolated normal squamous epithelium and of dysplastic epithelium. In culture, two normal squamous epithelia secreted a large amount (〉 2000 pg/48 h/106 cells), whereas 8 dysplasia epithelia secreted an extremely small amount (〈 10 pg/48 h/106 cells). About one-third of patients with SCC had a raised serum IL-6 value. IL-6 production may help to differentiate between SCC and adenocarcinoma of the uterine cervix. IL-6 regulation seems to change in the course of SCC carcinogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01370929
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Interleukin-6 (IL-6) production in carcinoma of the cervix (1995)
    Springer
    Archives of gynecology and obstetrics 258 (1995), S. 25-33 
    Details
    ISSN: 1432-0711
    Keywords: Key words: Interleukin-6 (IL-6) ; Carcinoma of the uterine cervix ; Histologic type ; Carcinogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Interleukin-6 (IL-6) is a pleiotropic cytokine that is not only a mediator in major immunologic reactions but also a growth factor of keratinocytes. We studied the IL-6 secretion in vitro of 15 human cell lines derived from both squamous cell carcinoma (SCC) and adenocarcinoma of the uterine cervix. Four of the eight well differentiated SCC secreted a large amount (〉1500 pg/48 h/106 cells) of IL-6 in nude mice. In contrast, poorly differentiated SCC cell lines and all of the 7 adenocarcinoma cell lines secreted a small amount (〈500 pg/48 h/106 cells of IL-6). The expression of IL-6 mRNA of the cell lines correlated well with their IL-6 secretion potential. However, the expression of IL-6 receptor did not correlate with the IL-6 secretory potential. We also studied the IL-6 secretion of freshly isolated normal squamous epithelium and of dysplastic epithelium. In culture, two normal squamous epithelia secreted a large amount (〉2000 pg/48 h/106 cells), whereas 8 dysplasia epithelia secreted an extremely small amount (〈10 pg/ 48 h/106 cells). About one-third of patients with SCC had a raised serum IL-6 value. IL-6 production may help to differentiate between SCC and adenocarcinoma of the uterine cervix. IL-6 regulation seems to change in the course of SCC carcinogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01370929
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    DNA polymorphisms in the ψβ1- and β-globin gene regions in asian macaques (1991)
    Springer
    Biochemical genetics 29 (1991), S. 177-187 
    Details
    ISSN: 1573-4927
    Keywords: DNA polymorphisms ; ψβ1-globin gene ; δ-globin gene ; β-globin gene ; macaques
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract DNA polymorphisms in the ψβ1-β-globin gene region in nine Asian macaques(Macaca fuscata, M. mulatta, M. nemestrina, M. cyclopis, M. fascicularis, M. arctoides, M. radiata, M. maura, andM. assamensis) were examined using several restriction endonucleases and the human ψβ1, δIVS2, and βIVS2 probes. TheBamHI site 3′ to the β-globin gene was polymorphic inM. fuscata andM. mulatta, while the HincII site and the EcoRI site in the ψβ1-globin gene region was highly polymorphic inM. fuscata andM. mulatta, respectively. These polymorphic sites also seem to be present in other Asian macaques. The present study of the polymorphism at theBamHI site 3′ to the β-globin gene in Asian macaques supports, at the nuclear DNA level, the idea that thefascicularis group includingM. fuscata, M. mulatta, M. cyclopis, andM. fascicularis is different from other Asian macaque groups.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00554210
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    DNA polymorphisms in the ε- and γ-globin gene regions in asian macaques (1991)
    Springer
    Biochemical genetics 29 (1991), S. 189-202 
    Details
    ISSN: 1573-4927
    Keywords: DNA polymorphism ; ε-globin gene ; γ-globin gene ; macaques
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract DNA polymorphisms in the ε- and γ-globin gene regions in nine Asian macaques(Macaca fuscata, M. mulatta, M. nemestrina, M. cyclopis, M. fascicularis, M. arctoides, M. radiata, M. maura, andM. assamensis) were examined using several different restriction endonucleases and the human ε and γIVS2 probes.M. fuscata andM. mulatta had highly polymorphic sites(BglII andHincII, respectively) in the ε-globin gene region. TheBamHI site in the γ-globin gene region was highly polymorphic inM. mulatta, while theBglII andHindIII sites in the γ-globin gene region were highly polymorphic inM. fuscata andM. mulatta. The presence of the γ-globin gene triplication was frequently observed inM. fuscata. The gain or loss of an additionalBglII site between two γ-globin genes in Asian macaques seems to be very meaningful for discussing genetic relationships among them.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00554211
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    DNA polymorphisms in the ψβ1- and β-globin gene regions in asian macaques (1991)
    Springer
    Biochemical genetics 29 (1991), S. 177-187 
    Details
    ISSN: 1573-4927
    Keywords: DNA polymorphisms ; ψβ1-globin gene ; δ-globin gene ; β-globin gene ; macaques
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract DNA polymorphisms in the ψβ1-β-globin gene region in nine Asian macaques(Macaca fuscata, M. mulatta, M. nemestrina, M. cyclopis, M. fascicularis, M. arctoides, M. radiata, M. maura, andM. assamensis) were examined using several restriction endonucleases and the human ψβ1, δIVS2, and βIVS2 probes. TheBamHI site 3′ to the β-globin gene was polymorphic inM. fuscata andM. mulatta, while the HincII site and the EcoRI site in the ψβ1-globin gene region was highly polymorphic inM. fuscata andM. mulatta, respectively. These polymorphic sites also seem to be present in other Asian macaques. The present study of the polymorphism at theBamHI site 3′ to the β-globin gene in Asian macaques supports, at the nuclear DNA level, the idea that thefascicularis group includingM. fuscata, M. mulatta, M. cyclopis, andM. fascicularis is different from other Asian macaque groups.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02401811
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    DNA polymorphisms in the ε- and γ-globin gene regions in asian macaques (1991)
    Springer
    Biochemical genetics 29 (1991), S. 189-202 
    Details
    ISSN: 1573-4927
    Keywords: DNA polymorphism ; ε-globin gene ; γ-globin gene ; macaques
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract DNA polymorphisms in the ε- and γ-globin gene regions in nine Asian macaques(Macaca fuscata, M. mulatta, M. nemestrina, M. cyclopis, M. fascicularis, M. arctoides, M. radiata, M. maura, andM. assamensis) were examined using several different restriction endonucleases and the human ε and γIVS2 probes.M. fuscata andM. mulatta had highly polymorphic sites(BglII andHincII, respectively) in the ε-globin gene region. TheBamHI site in the γ-globin gene region was highly polymorphic inM. mulatta, while theBglII andHindIII sites in the γ-globin gene region were highly polymorphic inM. fuscata andM. mulatta. The presence of the γ-globin gene triplication was frequently observed inM. fuscata. The gain or loss of an additionalBglII site between two γ-globin genes in Asian macaques seems to be very meaningful for discussing genetic relationships among them.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02401812
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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