ISSN:
1435-1463
Keywords:
Vasopressin
;
messenger RNA
;
ribosomal RNA
;
total RNA
;
postmortem stability
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Postmortem stability of arginine-vasopressin (AVP) messenger RNA (mRNA) in the rat brain was studied comparing changes with those in the recovered amounts of total RNA and ribosomal RNA (rRNA). The amount of AVP mRNA and rRNA showed a decrease with increasing time interval after death (postmortem time), whereas the amount of total RNA did not alter with postmortem time. The half-life of AVP mRNA in the rat postmortem seemed to be approximately 16 hrs. The analysis of the ratio of AVP mRNA to 18S-rRNA suggested that AVP mRNA was degraded postmortem more rapidly than rRNA. These results suggest that autopsied human brains should be used for AVP mRNA study within a short postmortem time.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01253387
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