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  • Life and Medical Sciences  (2)
  • molecule-level embedment  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Nonlinear Optical Polymer Films Based on Sol-Gel Derived Polysilsesquioxane with Pendant Chromophoric Subunits Embedded in Size-matched Pores (2000)
    Springer
    Journal of sol gel science and technology 18 (2000), S. 137-144 
    Details
    ISSN: 1573-4846
    Keywords: sol-gel polysilsesquioxanes ; nonlinear optical polymer films ; molecule-level embedment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Two new hybrid nonlinear optical (NLO) polymeric films have been fabricated from the corresponding monomers, α, ω-bis(trimethoxysilyl)-1,4-dipropoxybenzenes bearing one or two moieties of pendant groups of N-(4)-nitrophenol-(L)-prolinol (NPP) on the spacer respectively by molecular design and “in-situ poling and sol-gel” process. These films are of enhanced thermal stability, extended temporal stability and higher second harmonic generation (SHG) susceptibilities. Their d 33 values are 2.0 × 10−8 esu and 3.2 × 10−8 esu., respectively. These properties can be ascribed to the molecule-level embedment of NPP moieties in size-matched pore of the polysilsesquioxanes and fixation of the orientation of the poled chromophore given by the pore formed after the alignment of NPP moieties. The structures and morphologies of the two polymeric films investigated by XRD, FT-IR, DSC, TGA, AFM, etc. show a close correlation with the SHG properties.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008764919860
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effects of recombinant CSF-1 on the blast cells of acute myeloblastic leukemia in suspension culture (1988)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 135 (1988), S. 55-62 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Recombinant hemopoietic colony-stimulating factors (CSFs), including GM-CSF, G-CSF and IL-3, have been shown to be effective stimulators of both self-renewal and terminal differentiation of blast stem cells in acute myeloblastic leukemia (AML). We have examined the activity of a fourth growth factor, recombinant CSF-1 (or M-CSF), on the growth of leukemic blasts in culture. CSF-1 was found to be active on some, but not all, blast populations. In sensitive cells, CSF-1 often stimulated the production of adherent blast cells incapable of division. This observation leads us to suggest that CSF-1 may be useful in the treatment of selected cases of AML.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041350108
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Expression of the CSF-1 gene in the blast cells of acute myeloblastic leukemia: Association with reduced growth capacity (1988)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 135 (1988), S. 133-138 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Myelopoietic growth factors are known to influence the growth in culture of malignant blast cells from human Acute Myeloblastic Leukemia (AML). We have used cDNA clones for the factor CSF-1 and its receptor fms to study DNA and RNA from the blasts of 25 AML patients. The CSF-1 gene was always in the germline configuration. CSF-1 mRNA was found in about half the blast populations. The cells were also studied for their growth properties in culture. A highly significant association was found between CSF-1 expression and poor growth in suspension culture. Most blast populations expressed fms; the number of fms expression negative samples was too small to permit the detection of any association between fms expression and growth or any interaction between the effects of the expression of the growth factor and its receptor. We propose that CSF-1 may be an important part of the mechanism determining the balance between self-renewal and determination in AML blast clones.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041350119
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    Paper (German National Licenses)
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