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  • Drug Efficacy  (1)
  • plasma and synovial fluid  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Osmosin: its effect on plasma and synovial fluid kinetics of indomethacin (1985)
    Springer
    European journal of clinical pharmacology 27 (1985), S. 689-691 
    Details
    ISSN: 1432-1041
    Keywords: indomethacin ; Osmosin ; plasma and synovial fluid ; polyarthritis ; inflammation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary ‘Osmosin’ (sodium indomethacin trihydrate, now withdrawn) produced a constant rate of release of indomethacin into the gut. Paired plasma and synovial fluid samples were obtained at regular intervals following a single dose of ‘Osmosin’ (19 patients) and after continuous daily dosing (15 patients). Indomethacin is rapidly absorbed and plasma concentrations maintained in the range 0.3 to 0.6 µg/ml after the first 4 h. Equilibrium between plasma and synovial fluid occurs, with SF/plasma ratios 0.74 to 0.82 12–24 h after a single dose and up to 0.96 thereafter. The indomethacin synovial fluid/plasma profile is changed by Osmosin from the pattern of a short half-life drug to the pattern typical of a long half-life drug. Results from serial samples obtained by use of indwelling cannulae (in vein and knee joint) show close agreement with our single paired sampling technique. Our method may have theoretical disadvantages but it has many practical advantages.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00547050
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Intra-articular steroids: Confounder of clinical trials (1991)
    Springer
    Clinical rheumatology 10 (1991), S. 38-42 
    Details
    ISSN: 1434-9949
    Keywords: Intra-Articular Steroids ; ESR ; C-Reactive Protein ; Rheumatoid Arthritis ; Drug Efficacy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of intra-articular (i-a) steroid injection on ESR and C-reactive protein (CRP) in rheumatoid arthritis (RA) was investigated. One week following injection of 1 or 2 knees there was a significant fall in ESR (p〈0.0001) and CRP (p〈0.01) in a cohort of 20 RA patients. The mean drop for both ESR and CRP was 46%. This effect lasted over a variable period up to 6 months. A survey of 50 published drug efficacy studies in RA revealed that, while 44 used ESR and 20 CRP as efficacy measures, 37 neither excluded nor recorded i-a steroid injections during the study. Steroid injections were excluded in 8 studies and recorded in 5, being used as an outcome measure in 2 of these. It is recommended that the frequency with which i-a injections are used in drug efficacy studies is reported and that they are avoided in the 3 months preceding an outcome measurement if ESR or CRP are being used as outcome measures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02208031
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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