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Digitale Medien

Comparative bioavailability: Eight commercial prednisone tablets (1976)

Sullivan, Timothy J. ; Hallmark, Margarette R. ; Sakmar, Ermelinda ; [weitere]

Springer

Journal of pharmacokinetics and pharmacodynamics 4 (1976), S. 157-172

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Details

ISSN: 1573-8744

Schlagwort(e): prednisone bioavailability ; elimination half-lives of prednisone and prednisolone ; prednisone and prednisolone plasma levels following prednisone

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie

Notizen: Abstract Two four-treatment crossover bioavailability studies were performed in panels of 12 adult male volunteers with eight different commercial prednisone tablets. Plasma samples from the first study were assayed by radioimmunoassay for both prednisone and prednisolone. Plasma samples from the second study were assayed for prednisolone only. Statistical analyses of the data showed significant differences in the rate of appearance of prednisolone in plasma, but not in the amount convened to prednisolone. Some observations are made on the relationships between prednisone and prednisolone concentrations in plasma following oral administration of prednisone.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01086151

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