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  • Occupational exposure  (2)
  • primary gastric lymphoma  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Investigation of a cluster of ten cases of Hodgkin’s disease in an occupational setting (1996)
    Springer
    International archives of occupational and environmental health 68 (1996), S. 224-228 
    Details
    ISSN: 1432-1246
    Keywords: Key words Hodgkin’s disease ; Occupational exposure ; Nested case-control study.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The objective of this study was to identify occupational exposures that might be etiologically linked to an unusual cluster of ten cases of Hodgkin’s disease. The cases were identified within the active workforce of a large chemical manufacturing firm over a 23-year period by the medical director of the facilities. Based on comparison with regional cancer incidence rates, the standardized incidence ratio for Hodgkin’s disease was 497 (95% confidence interval: 238–915) for the period from the construction of the facilities in 1966 through early 1992. A nested case-control study was undertaken with 200 controls selected according to case-cohort sampling. Simultaneously, efforts were initiated to confirm and characterize each case more fully. Occupational exposures were identified and categorized using process, work history, medical record, and industrial hygiene data. Tissue slides were available for eight cases and a second review confirmed the diagnosis of Hodgkin’s disease. For one case, a final diagnosis of large-cell anaplastic lymphoma was determined after histology review. Among 214 different chemical agents studied, eight were identified to which three or more of the cases had been exposed prior to the date of their initial diagnosis. Exposure odds ratios were statistically elevated for five of these agents; dose-response evaluations for two of the agents, ethylene oxide and benzene, failed to provide additional support for a causal relationship. In conclusion, although several statistical associations were identified, no substance emerged as a likely candidate for explaining the observed Hodgkin’s disease cluster.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00381432
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Investigation of a cluster of ten cases of Hodgkin's disease in an occupational setting (1996)
    Springer
    International archives of occupational and environmental health 68 (1996), S. 224-228 
    Details
    ISSN: 1432-1246
    Keywords: Hodgkin's disease ; Occupational exposure ; Nested case-control study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The objective of this study was to identify occupational exposures that might be etiologically linked to an unusual cluster of ten cases of Hodgkin's disease. The cases were identified within the active workforce of a large chemical manufacturing firm over a 23-year period by the medical director of the facilities. Based on comparison with regional cancer incidence rates, the standardized incidence ratio for Hodgkin's disease was 497 (95% confidence interval: 238–915) for the period from the construction of the facilities in 1966 through early 1992. A nested case-control study was undertaken with 200 controls selected according to case-cohort sampling. Simultaneously, efforts were initiated to confirm and characterize each case more fully. Occupational exposures were identified and categorized using process, work history, medical record, and industrial hygiene data. Tissue slides were available for eight cases and a second review confirmed the diagnosis of Hodgkin's disease. For one case, a final diagnosis of large-cell anaplastic lymphoma was determined after histology review. Among 214 different chemical agents studied, eight were identified to which three or more of the cases had been exposed prior to the date of their initial diagnosis. Exposure odds ratios were statistically elevated for five of these agents; dose-response evaluations for two of the agents, ethylene oxide and benzene, failed to provide additional support for a causal relationship. In conclusion, although several statistical associations were identified, no substance emerged as a likely candidate for explaining the observed Hodgkin's disease cluster.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00381432
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Specific detection of Helicobacter pylori and non–Helicobacter pylori flora in small- and large-cell primary gastric B-cell non-hodgkin's lymphoma (1997)
    Springer
    Annals of oncology 8 (1997), S. 33-36 
    Details
    ISSN: 1569-8041
    Keywords: bacterial flora ; Helicobacter pylori ; immunohisochemistry ; MALT ; primary gastric lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Primary gastric non-Hodgkin's lymphomas possibly develop in response to local infection by Helicobacter pylori (H. pylori). We investigated the presence of H. pylori and non–H. pylori flora histologically in small- and large-cell primary gastric lymphoma using a specific staining method. Materials and methods: Specimens of 52 cases of primary gastric lymphoma(17 small cell, 35 large cell) were stained with modified Giemsa (MG) and immunohistochemically using a polyclonal antibody against H. pylori (IHC). Results: Thirty-two cases (61.5%) (small cell 76% versus large cell 53%,P 〉 0.05) showed immunoreactivity for H. pylori in the mucosa surrounding the tumor. Remarkable, there waslocalization of H. pylori in the neck of the gastric glands in 3 cases.Non– H. pylori flora was seen in 35 cases (76.3%) (small cell53% versus large cell 74%,P 〉 0.05). In 20cases, this non– H. pylori flora was mixed with H. pylori. Five cases showed no bacterial flora at all. Conclusions: (1)Using immunohistochemistry, the prevalence of gastriclymphoma cases with H. pylori (61.5%) approximates that of H. pylori in the normal population. (2) No statistical difference was found between the occurrence of H. pylori and non–H. pyloribacterial flora in small- versus large-cell lymphoma. (3) Our results suggest that H. pylori may not be the only etiologic factor in primary gastric lymphoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008205510594
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Specific detection of Helicobacter pylori and non–Helicobacter pylori flora in small- and large-cell primary gastric B-cell non-hodgkin's lymphoma (1997)
    Springer
    Annals of oncology 8 (1997), S. 33-36 
    Details
    ISSN: 1569-8041
    Keywords: bacterial flora ; Helicobacter pylori ; immunohisochemistry ; MALT ; primary gastric lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Primary gastric non-Hodgkin's lymphomas possibly develop inresponse to local infection by Helicobacter pylori (H. pylori). Weinvestigated the presence of H. pylori and non–H. pylori florahistologically in small- and large-cell primary gastric lymphoma using aspecific staining method. Materials and methods: Specimens of 52 cases of primary gastric lymphoma(17 small cell, 35 large cell) were stained with modified Giemsa (MG) andimmunohistochemically using a polyclonal antibody against H. pylori (IHC). Results: Thirty-two cases (61.5%) (small cell 76% versuslarge cell 53%,P 〉 0.05) showed immunoreactivityfor H. pylori in the mucosa surrounding the tumor. Remarkable, there waslocalization of H. pylori in the neck of the gastric glands in 3 cases.Non– H. pylori flora was seen in 35 cases (76.3%) (small cell53% versus large cell 74%,P 〉 0.05). In 20cases, this non– H. pylori flora was mixed with H. pylori. Five casesshowed no bacterial flora at all. Conclusions: (1)Using immunohistochemistry, the prevalence of gastriclymphoma cases with H. pylori (61.5%) approximates that of H. pylori in the normal population. (2) No statistical difference was foundbetween the occurrence of H. pylori and non–H. pyloribacterial flora in small- versus large-cell lymphoma. (3) Our resultssuggest that H. pylori may not be the only etiologic factor in primarygastric lymphoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008205510594
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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