ISSN:
1573-8272
Keywords:
fluid dynamics
;
regulation
;
IMC-based PID control
;
two-phase flow theory
Source:
Springer Online Journal Archives 1860-2000
Topics:
Process Engineering, Biotechnology, Nutrition Technology
Notes:
Abstract Expanded-bed adsorption (EBA) is a technique for the purification of proteins from cellular debris in downstream processing. An expanded bed presents the possibility of protein recovery in a single step, eliminating the often costly clarification processing steps such as ultrafiltration, centrifugation, and precipitation. An obstacle to the successful commercialization of this technology is the inability to accurately monitor and control the bed height in these systems. In this paper, we present an overview of work in our laboratory addressing monitoring, modeling, and control strategies as applied to EBA. First, we present the development of a level measurement technique based upon ultrasonics. It is shown that this technique has great promise for bed-height measurement in EBA systems. Second, we present modeling strategies for bed-height dynamics due to flow rate and fluid property changes, and lastly, we show how monitoring and modeling information can be used for the control and regulation of bed expansion.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008173007076
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