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  • 1
    Electronic Resource
    Electronic Resource
    Myocardial infarction following acute occlusion and reperfusion of the septal coronary artery (1985)
    Springer
    Basic research in cardiology 80 (1985), S. 670-676 
    Details
    ISSN: 1435-1803
    Keywords: coronary reperfusion ; interventricular septum ; myocardial infarction ; septal artery ; triphenyl tetrazolium chloride
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary It has been demonstrated that temporary occlusion of major epicardial arterics of the dogs produces a nontransmural myocardial infarction (MI) whose size is reduced by early reperfusion. This study was undertaken to determine the location and extent of MI following acute occlusion and reperfusion of the septal artery (SA). The SA was occluded for four hours in group I (7 dogs). Occlusion time for group II (6 dogs) was 2 hours and for group III (6 dogs) was 1 hour, followed by 2 and 3 hours of reperfusion, respectively. The hearts were then removed and cut into transverse slices from base to apex. The triphenyl tetrazolium chloride technique identified the areas of infarction, which were quantitated with a microcomputer-based graphics system. To determine the extent of necrosis across the interventricular septum (IVS), the IVS was divided into 5 transverse segments of equal depth and the amount of MI was determined for each. In group I, MI involved 3.42±0.9% (mean±SEM) of the left ventricle (LV) and 13.49±3.4% of the IVS. In group II, 6.11±1.3% of the LV and 25.00±5.5% of the IVS were infarcted. In group III, 5.63±1.3% of the LV and 31.9±14.3 % of the septum were infarcted. MI was larger on the left side of the IVS than on the right in all groups, and the extent of MI did not differ significantly between the three groups. This study showed that early reperfusion of the SA did not reduce MI as reported for other coronary beds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01907866
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  • 2
    Electronic Resource
    Electronic Resource
    Relationship between coronary collateral growth in the dog and ischemic bed size (1981)
    Springer
    Basic research in cardiology 76 (1981), S. 305-312 
    Details
    ISSN: 1435-1803
    Keywords: septal artery ; circumflex occlusion ; right cor. occlusion ; collateral blood flow distribution ; collateral pattern
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wir untersuchten zwei Modelle des Koronarverschlusses: Dreimonatige Okklusion des Ramus circumflexus und rechte Koronarokklusion. Nach Koronarverschluß fand Kollateralentwicklung in normal aktiven Hunden statt. Kollateralperfusion wurde an einem isolierten Herzpräparat gemessen. Die Resultate erwiesen, daß ein gewisses Schema der Kollateralentwicklung zugrunde liegt. Kollateralperfusion was im allgemeinen zum linken Herzen mit Ramus-circumflexus-Okklusion orientiert und zum rechten herzen mit rechtem Koronarverschluß. Obwohl die Hauptkollateralisierung über epikardiale Kollateralen stattfand, fanden wir aktive intramyokardiale Entwicklung von der Septalarterie in beiden Modellen. Kollateralentwicklung zum Ramus circumflexus nach Verschluß war 6.54mal größer als die zur rechten Koronararterie. Die Resultate deuten auf eine Beziehung zwischen Kollateralwachstum und Größe des ischämischen Gebietes hin.
    Notes: Summary Two models of gradual coronary occlusion (Ameroid method) were compared in this study: 3 months circumflex and 3 months right coronary occlusion. Following coronary occlusion, the collaterals developed in intact, normally active dogs. The collateral flows were assessed in an isolated heart preparation. The results indicated a pattern for collateral development. Collateral flow was directed primarily toward the left heart with circumflex occlusion, and toward the right heart with right occlusion. Although dominant collateralization was via epicardial collaterals, intramyocardial septal collaterals strongly participated in growth development of both models. Collateral growth to the circumflex with circumflex occlusion was 6.54 fold greater than collateral growth to the right coronary artery with right occlusion. The data suggest a relationship between collateral growth and ischemic bed size.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01907774
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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