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  • 1
    Electronic Resource
    Electronic Resource
    Excitative effects in anaesthetized rabbits from subarachnoidally injected iso- and hyperosmolar solutions of iohexol and metrizamide (1984)
    Springer
    Neuroradiology 26 (1984), S. 131-136 
    Details
    ISSN: 1432-1920
    Keywords: Contrast media ; neurotoxicity ; chemotoxicity ; osmolality ; subarachnoid injection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Equimolar doses of iohexol and metrizamide (0.48 mmol/kg body weight = 185 mg I/kg), administered in solutions iso- and hyperosmolar to the CSF, were injected subarachnoidally into rabbits under pentobarbital anaesthesia. No excitative effects of iohexol were observed in the behaviour of the rabbits during a 3-h period immediately after the injection. Metrizamide caused significant, severe excitative effects, ranging from hyperexcitability to repeated generalized seizures. The frequency and severity of excitative effects were independent of the osmolality of the metrizamide solutions injected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00339861
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Interaction between chlorpromazine and intrathecally injected non-ionic contrast media in non-anaesthetized rabbits (1984)
    Springer
    Neuroradiology 26 (1984), S. 235-240 
    Details
    ISSN: 1432-1920
    Keywords: Chlorpromazine ; contrast media ; interaction ; neurotoxicity ; subarachnoid injection ; subdural injection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary During a 14-day period, 45 of 78 rabbits were treated intravenously with chlorpromazine (5 mg kg-1 day-1). Metrizamide or iohexol was injected subarachnoidally and the neurotoxic effects of each substance on rabbit behaviour were evaluated for 3 h in both chlorpromazine-treated and non-treated rabbits. Chlorpromazine increased both the excitative and the depressive effects of metrizamide and the depressive effects of iohexol. No signs of excitation were observed in chlorpromazine-treated and non-treated rabbits after subarachnoid injections of iohexol. In spite of a free flow of clear fluid from the needle both before and after the intended subarachnoid injection, radiography disclosed that 26 of 67 suboccipital injections inadvertently resulted in a subdural deposition of the contrast medium. Contrast medium effects following subdural injection significantly differed from those following subarachnoid injection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00342420
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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