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  • 1
    Electronic Resource
    Electronic Resource
    The relationship between theophylline clearance and age in adult life (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 29-34 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; asthma ; clearance ; age ; adults ; elderly ; normal subjects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Fifty three subjects (31 normal volunteers and 22 patients with asthma) between the ages of 20 and 87 years had their theophylline clearance measured. Volume of distribution (V) and terminal elimination half-life (t1/2) were also calculated in the volunteers who received i.v. theophylline. Although patients tended to have higher clearance values than volunteers, in both groups the oldest third had the lowest clearances. For the combined group (corrected for the patient effect) the oldest third (mean age 70 years) had a mean clearance of 0.53 versus 0.72 for the middle third (mean age 47 years) and 0.73 ml/min/kg CBW for the youngest third (mean age 26 years). There was no statistically significant age related change in V/kg CBW but t1/2 did rise with increasing age. Thus, although clearance does not fall with increasing age during younger adult life, there is a fall during late adult life becoming apparent in the seventh, eighth and ninth decades.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561019
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Methods of comparing pharmacokinetics of slow release preparations: a comparison of “Theo-Dur” and “Phyllocontin” in patients with asthma (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 313-317 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; aminophylline ; slow release formulations ; bronchial asthma ; pharmacokinetics ; methods of comparison
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of two slow release theophylline preparations “Theo-Dur” (T) containing theophylline only and “Phyllocontin” (P) containing aminophylline have been compared in 12 patients with asthma. Each patient received both treatments in random order. The dose of treatment administered 12 hourly was increased or decreased to produce plasma theophylline concentrations of 10–20 mg/l at clinic visits normally 7 to 8 h after dosing. Pharmacokinetic studies were carried out after at least one week's treatment with this dose. After the first study day patients were crossed over to the second treatment at a dosage providing a similar amount of theophylline. They returned for a second study day after at least one week. Comparison of the dose corrected AUC, time to peak concentrations, within patient coefficients of variation (CV), number of concentration time points falling within 25% of Cmax and percentage fluctuations in plasma concentration showed no significant differences between the two preparations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00541535
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    XPS and SIMS Investigation of Covalently Bound Lipid on the Wool Fibre SurfacePaper presented at the 4th International Conference on Adhesion and Surface Analysis (1996)
    Chichester [u.a.] : Wiley-Blackwell
    Surface and Interface Analysis 24 (1996), S. 704-710 
    Details
    ISSN: 0142-2421
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Alcoholic alkali solutions, such as potassiumt-butoxide int-butanol and potassium hydroxide in ethanol, have been known to remove the covalently bound lipid from the wool fibre surface. In this study, x-ray photoelectron spectroscopy (XPS) and secondary ion mass spectrometry (SIMS) have been used to investigate the surface characteristics of unprocessed wool fibres (both base section and weathered tips), wool fabric and the relative effects of potassiumt-butoxide and potassium hydroxide treatments. Results comparing the fibre base and tip confirm that the weathering may result in partial loss of the covalently bound lipid from the tip. In addition, a loss of sulphur has been observed. While the extent of sulphur oxidation on the surface of the base section is insignificant, the tip section may have up to 30% oxidized sulphur. There is no apparent difference between the fibres and the fabric used in this study regarding the levels of carbon, sulphur and oxidation. Potassiumt-butoxide is found to be less effective than potassium hydroxide in removing the surface bound lipid. An explanation is given which supports a hypothesis that the bound lipid is located not only at the outer most surface, but that it is also trapped within the underlying protein layer. The potassiumt-butoxide, due to its bulky molecular structure, may not have easy access to the trapped lipid. While the extent of oxidation of surface sulphur after potassiumt-butoxide treatment is higher compared to that after potassium hydroxide treatment, the levels of sulphur loss caused by these two reagents are similar. The removal of bound surface lipid for fabric is more effective than for fibres. It is suggested that fine-scale damage to the fibre, which has been observed to occur during physical processing, is responsible for this difference.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 4
    Electronic Resource
    Electronic Resource
    Photostabilizing effect of Ni(II) chelates in polymers. II. Effect of diamagnetic chelates on polypropylene phosphorescence (1974)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 18 (1974), S. 2805-2807 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Examination of the phosphorescence emission form polypropylene shows the lifetime of the emission to be unaffected by a hydroxybenzophenone light stabilizer but significantly shorted by a diamagnetic Ni(II) chelate stabilizer.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1974.070180921
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    A Rapid, Accurate Technique for Determining Densities of High Explosives (1977)
    Weinheim : Wiley-Blackwell
    Propellants, Explosives, Pyrotechnics 2 (1977), S. 81-84 
    Details
    ISSN: 0721-3115
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: An improved gas comparison pycnometer has been developed, based on precise differential pressure measurements coupled with a sample volume compensator. Using helium gas, volumes of solid and powdered explosives can be measured to a precision approaching one part in lo4. Coupled with a precise mass measurement, these volumes allow densities with an uncertainty of ∼± 0.002 g/ml to be inferred. Measurements performed on various explosives have allowed assessment of the purity and homogeneity of individual samples. It is also possible to infer void percentage or porosity in pressed explosive pellets.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prep.19770020405
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    Paper (German National Licenses)
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