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  • 1
    Electronic Resource
    Electronic Resource
    Interaction of cimetidine with bisoprolol (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 109-110 
    Details
    ISSN: 1432-1041
    Keywords: bisoprolol ; cimetidine ; interaction ; renal clearance ; tubular secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00610393
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  • 2
    Electronic Resource
    Electronic Resource
    Cimetidine-procainamide pharmacokinetic interaction in man: Evidence of competition for tubular secretion of basic drugs (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 339-345 
    Details
    ISSN: 1432-1041
    Keywords: cimetidine ; procainamide ; interaction ; renal clearance ; tubular secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The hypothesis that basic drugs can compete for active tubular secretion by the kidney was tested in six healthy volunteers by comparing the single dose pharmacokinetics of oral procainamide before and during a daily dose of cimetidine. The area under the procainamide plasma concentration-time curve was increased by cimetidine by an average of 35% from 27.0±0.3 µg/ml·h to 36.5±3.4 µg/ml·h. The elimination half-life increased from an harmonic mean of 2.92 to 3.68 h. The renal clearance of procainamide was reduced by cimetidine from 347±46 ml/min to 196±11 ml/min. All these results were statistically significant (p〈0.016). The area under the plasma concentration-time curve for n-acetylprocainamide was increased by a mean of 25% by cimetidine due to a significant (p〈0.016) reduction in renal clearance from 258±60 ml/min to 197±59 ml/min. The data suggests that cimetidine inhibits the tubular secretion of both procainamide and n-acetylprocainamide, and, if so, represents the first documented evidence for this type of drug interaction in man. The clinical implications from this study necessitate dosage adjustments of procainamide in patients being concomitantly treated with cimetidine. The interaction is pertinent not only for basic drugs that are cleared by the kidney, but also for metabolites of basic drugs and endogenous substances which require active transport into the lumen of the proximal tubule of the kidney for their elimination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01037945
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  • 3
    Electronic Resource
    Electronic Resource
    On the gas-phase reaction of C3O2+. with C3O2 (1994)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 29 (1994), S. 540-546 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The gas-phase, ion molecule reaction between C3O2+. and C3O2 has been studied by both double-focusing and ion trap mass spectrometry, rationalized by the formation of a dimeric, odd electron cation [C6O4]+. which decomposes extensively through sequential CO losses giving rise to [C5O3]+. and [C4O2]+. ions. The thermodynamics of this process have been investigated by means of ab initio calculation performed on the above species using different basis sets (STO-3G, 3-21G and 6-31G*).
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210291005
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  • 4
    Electronic Resource
    Electronic Resource
    Structural investigation of the hydroxy-propynal molecular ion (1993)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 7 (1993), S. 132-137 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: A formyl ketenyl platinum derivative, trans-μ1-(PCy3)2(H)Pt[C(CHO)CO] (where Cy represents a cyclohexyl group), when reacted with HCl, gives a C3H2O2 species among the reaction products. The structure was investigated mass spectrometrically by study of the reactions of metastable ions, and the information gained was combined with data from theoretical calculations to rationalize the structure of the C3H2O2 molecule.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290070204
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  • 5
    Electronic Resource
    Electronic Resource
    Collisions of C60+· and C602+ at fluorinated and non-fluorinated self-assembled monolayer filmsPaper delivered at the llth Informal Meeting on Mass Spectrometry, Budapest, 1993. (1993)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 7 (1993), S. 693-699 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: We report here the spectra that result when singly and doubly charged buckminsterfullerene ions, C60+· and C602+, collide with self-assembled monolayer films at collison energies ranging from 125 to 320 eV. The surfaces were prepared by the spontaneous assembly of octadecanethiol (CH3(CH2)17SH), perdeuteroeicosanethiol (CD3(CD2)19SH), and 2-(perfluorooctyl)-ethanethiol (CF3(CF2)7CH17CH2SH) on vapor-deposited gold. The fluorinated surface causes the greatest conversion of kinetic energy into internal energy, more extensive fragmentation of doubly charged buckminsterfullerene C602+ is detected in collisions with this surface than in collisions with the alkanethiolate surfaces.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290070802
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    On the reactivity of C3O2 with [C3H6]+· (1995)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 30 (1995), S. 1049-1050 
    Details
    ISSN: 1076-5174
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jms.1190300716
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Determination of incident angle in radioisotope-excited EDXRF (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    X-Ray Spectrometry 22 (1993), S. 395-400 
    Details
    ISSN: 0049-8246
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Three different methods were used for the determination of the effective incident angle related to EDXRF when radioisotope annular sources are involved: weighted averaging, Compton peak method and minimization of the difference between the certificated and measured concetrations of six international standard samples. By measuring the Compton peak energies of various analytical reagent grade elements and compounds, it was found that the incoherent peak energy depends on the mean atomic number of the matrix, so the effective incident angle is also matrix dependent.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/xrs.1300220605
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  • 8
    Electronic Resource
    Electronic Resource
    Comparison of emission-transmission and elemental sensitivity Methods for determining the trace element content of biological samples (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    X-Ray Spectrometry 24 (1995), S. 193-200 
    Details
    ISSN: 0049-8246
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Two widely used concentration calculation techniques, emission-transmission and elemental sensitivity methods, were compared. In the determination of the trace element content of environmental materials (e. g. plants, soil), the mass absorption coefficients for the exciting and characteristic x-rays are dominated of the ‘non-detectable’, light major components. When using the elemental sensitivity method, these mass absorption coefficients must be a known a priori. When using the emission-transmission method, the combined attenuation of the incident and fluorescence x-rays within the specimen for the ith element is determined experimentally. The trace element content of biological materials was determined with both methods and the concentrations obtained were compared by t-test and one-way analysis of variance methods. In the case of available reference materials the concentration values obtained with these methods were compared with the certified values.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/xrs.1300240409
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