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Digitale Medien

The effects of nifedipine on platelet aggregation and plasma 6-keto-PGF1α, and its interaction with indomethacin (1985)

Murphy, M. B. ; Orchard, M. A. ; Conway, E. L. ; [weitere]

Springer

European journal of clinical pharmacology 29 (1985), S. 413-416

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Details

ISSN: 1432-1041

Schlagwort(e): nifedipine ; indomethacin ; whole blood aggregometry ; 6-keto-prostaglandin F1α ; blood pressure ; platelet aggregation ; healthy volunteers

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary Pre-incubation of human platelets with nifedipine in vitro or treatment of normal volunteers with nifedipine, 30 mg daily for one week, did not alter ADP induced aggregation measured by whole blood aggregometry. 6-oxo-Prostaglandin F1α remained undetectable in plasma following oral administration of nifedipine to normal volunteers. The hypotensive response to intravenous nifedipine administration was similar in spontaneously hypertensive rats pretreated with indomethacin or placebo. These results conflict with previous reports that nifedipine alters platelet aggregation and prostaglandin metabolism.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00613454

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