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  • 2005-2009  (65)
  • 1940-1944  (12)
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  • 1
    Book
    Book
    Time management for system administrators : [stop working late and start working smart] (2005)
    Beijing [u.a.] :O'Reilly,
    Details
    Title: Time management for system administrators : [stop working late and start working smart]
    Author: Limoncelli, Thomas A.
    Edition: 1. Aufl.
    Publisher: Beijing [u.a.] :O'Reilly,
    Year of publication: 2005
    Pages: XXIII, 200 S.
    ISBN: 0-596-00783-3
    Type of Medium: Book
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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    ZIB Catalog
    Zuse Institute Berlin get availability status
  • 2
    Electronic Resource
    Electronic Resource
    Papillary Intraductal Carcinoma with Extensive Secretory Endometrium-like Subnuclear Vacuolization (2005)
    Oxford, UK : Blackwell Publishing Ltd
    The @breast journal 11 (2005), S. 0 
    Details
    ISSN: 1524-4741
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1075-122X.2005.00151.x
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Age-dependent response of primary human dermal fibroblasts to oxidative stress: cell survival, pro-survival kinases, and entrance into cellular senescence (2005)
    Malden, USA : Blackwell Science Inc
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A central question in cell biology is how cells become senescent. After a finite number of cell divisions, normal cultured human cells enter a state of irreversible growth arrest, termed “replicative senescence.” Alternatively, oxidative stress in the form of hydrogen peroxide (H2O2) can render human dermal fibroblasts (HDFs) nonproliferative and quiescent, a phenomenon known as stress-induced premature senescence (SIPS). Although critical to the understanding of the pathophysiological basis of many diseases, there is no research to date that has simultaneously examined the interactions between age, oxidative stress, and SIPS. Therefore, the goals of this study were to examine in concert the interactions between these three factors in primary HDFs, and to test our central hypothesis that aging lowers the ability of primary HDFs to respond to oxidative stress. Our data provide, for the first time, evidence that aging dramatically reduces the capacity of primary HDFs to respond to the challenge of hydrogen peroxide. Specifically, aged HDFs showed decreased cell viability, decreased phosphorylation (activation) of pro-survival kinases (Akt and ERK 1/2), and increased entrance into a senescent state when compared with their younger counterparts. Another important conclusion of this study is that blockade of transforming growth factor-β1 had a pronounced “rescue effect” in the aged, preventing entrance of HDFs into cellular senescence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1524-475X.2005.00079.x
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    066
Direct Comparison of Adenoviral and Adeno-Associated Viral Vectors for Efficiency of Gene Transfer in Ischemic Wound (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Tissue ischemia is a common occurrence in many disease processes including chronic wounds, stroke, solid tumors, and myocardial infarction. The application of gene delivery for healing of wounds has demonstrated increasing therapeutic promises in animal models. Adenoviral vectors have been successfully used for gene delivery to the ischemic wound. However, these vectors typically demonstrate short, transient transgene expression while eliciting significant cytotoxic immune response. Adeno-associated viral vectors (AAV) do not have those limitations; however, scant information is available about their transfection efficiency under low-oxygen tension. The goal of this study was to compare AAV vector with adenoviral vector in terms of relative efficiency of gene delivery and cytotoxic immune response in ischemic wounds. Reporter constructs Ad5-LacZ and AAV-LacZ (108 pfu/wound) were injected onto the dermis of rabbit ear prior to creation of ischemic wounds. Wounds were harvested at postoperative day 10. Frozen sections of the wounds were fixed in cold acetone and stained with an in situ β-gal staining kit. Intense expression of β-gal was observed with both vectors; however, transduction rates with AAV vector was approximately 10-fold lower than Adenovirus. Unlike Adenovirus, no noticeable inflammatory cell infiltration was observed with AAV injection. Even when the dosage of AAV was increased to 109 pfu/wound inflammatory cell infiltration remained negligible. Thus our data indicates that both AAV and adenoviral vectors are suitable to use in gene-therapy experiments in ischemic tissues. The particular advantage of AAV is the ability to transfect with higher doses while at lower dose maximal transfection rate seems to be more with Adenovirus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130215bn.x
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Letter to the Editor (2005)
    350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . : Blackwell Publishing, Inc.
    Risk analysis 25 (2005), S. 0 
    Details
    ISSN: 1539-6924
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0272-4332.2005.00561.x
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    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    006
Reduction of Scarring by Silicone in the Rabbit Ear Model (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Hypertrophic scars can be reduced by application of silicone dressing; however, the detailed mechanism of silicone action is still unknown. It is known that silicone gel sheets cause a hydration of the epidermal layer of the skin. An in vitro coculture experiment has shown that hydration of keratinocytes has a suppressive effect on the metabolism of the underlying fibroblasts resulting in reduced collagen deposition. We tested the hypothesis that silicone gel sheeting in vivo has a beneficial effect on scar reduction by a reduction in keratinocyte stimulation, with a resulting reduction in dermal thickness.Silicone adhesive gel sheets were applied to scars in our rabbit ear model of hypertrophic scarring 14 days post wounding for a total of 14 days. Scarring was measured in this model by the Scar Elevation Index (SEI), a ratio of the scar height over normal skin, and the Epidermal Thickness Index (ETI), a ratio of the epidermal height of the scar over normal epidermis. Ultrastructural changes were investigated using electron microscopy (EM).SEIs were significantly reduced after only 2-week applications of silicone gel sheets versus untreated scars (1.18 ± 0.05 vs. 1.45 ± 0.09, respectively; P 〈 0.05)– corresponding to a 48.8% reduction of scar hypertrophy. The epidermal layer in scars was in general thicker than in unwounded skin. However, ETIs of untreated scars increased by 103% versus 71% after silicone gel treatment – corresponding to a significant reduction of epidermal thickness by 24.4%. EM showed a basal layer in untreated scars that was very different than normal skin with many vacuoles at the basement membrane level, while silicone gel-treated scars had a basal cell layer which resembled unwounded epidermis.Our findings demonstrate that 2 weeks of silicone gel application at a very early onset of scarring reduces dermal thickness which appears to be due to a reduction in keratinocyte stimulation. These findings are consistent with our coculture results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130215f.x
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    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Cardiac Allograft Aortic Dissection: Successful Repair Using a Composite Valve Graft and Modified-Cabrol Coronary Reconstruction (2005)
    350 Main Street , Malden , MA 02148-5020 , USA and 9600 Garsington Road , Oxford OX4 2XG , England . : Blackwell Science Inc
    Journal of cardiac surgery 20 (2005), S. 0 
    Details
    ISSN: 1540-8191
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract  We report a 55-year-old man, the recipient of a cardiac allograft for ischemic cardiomyopathy 9 years earlier, who presented with progressive aortic root dilation, worsening aortic insufficiency, and an incidentally discovered chronic type A aortic dissection limited to the donor aorta. The patient was taken to the operating room, and the aortic dissection successfully repaired using standard reoperative techniques. This is the sixth case reported in the literature, and only the fourth survivor. To our knowledge, this case represents the first successful repair, of a limited aortic dissection of the donor aorta postcardiac transplantation, using a composite valve graft and modified-Cabrol coronary reconstruction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8191.2005.200467.x
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    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Association of Single Coronary Artery and Congenital Bicuspid Aortic Valve with Review of Literature (2005)
    350 Main Street , Malden , MA 02148-5020 , USA , and P.O. Box 1354, Garsington Road , Oxford OX4 2DQ , UK . : Blackwell Science Inc
    Journal of interventional cardiology 18 (2005), S. 0 
    Details
    ISSN: 1540-8183
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A 59-year-old white male presents to our hospital with shortness of breath, bilateral lower extremities swelling, an ejection systolic murmur, and S4 gallop. Echocardiography revealed a congenital bicuspid aortic valve (BAV). Subsequent coronary angiogram revealed a single coronary artery arising as a main trunk from the left coronary sinus. We report the second case of a single coronary artery and congenital BAV.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8183.2005.00067.x
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    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Best Estimated Aroma and Taste Detection Threshold for Guaiacol in Water and Apple Juice (2005)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 70 (2005), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: : Alicyclobacillus acidoterrestris can produce sufficient guaiacol (methoxyphenol), a metabolic by-product of the bacterium, in apple juice to cause a detectable taint characterized by an antiseptic off-odor or distinct medicinal flavor and lingering aftertaste. Bacterial spoilage may not be visibly detectable. The objective of this study was to determine the best estimate threshold (BET) for detection of guaiacol in water and commercial pasteurized apple juice from concentrate using the forced-choice ascending concentration method of limits with an experienced 17-member sensory panel. The mean BET for aroma detection of guaiacol in water and apple juice was 0.48 ppb and 0.91 ppb, respectively. The mean BET for taste detection of guaiacol in water and apple juice was 0.17 ppb and 0.24 ppb, respectively. Individual aroma BET values ranged from 0.06 ppb to 4.71 ppb guaiacol in water and 0.17 ppb to 4.71 ppb for guaiacol in apple juice. Individual taste BET values ranged from 0.01 ppb to 4.71 ppb for guaiacol in water and apple juice. The taste BET was equal to or lower than the aroma BET for guaiacol in both water and apple juice for all panelists. There was about a 500-fold range in guaiacol taste detection between panelists, with some individuals exhibiting a BET value as low as 10 ppt (trillion). The information should be useful for developing quality assurance sensory methodology to evaluate potential apple juice flavor spoilage by Alicyclobacillus spp.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.2005.tb07201.x
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    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Performance Information Systems for Emergency Response: Field Examination and Simulation of End-To-End Rural Response Systems (2005)
    Berkeley, Calif. : Berkeley Electronic Press (now: De Gruyter)
    Journal of homeland security and emergency management 2 (2005), S. 4 
    Details
    ISSN: 1547-7355
    Source: Berkeley Electronic Press Academic Journals
    Topics: Political Science , Sociology
    Notes: This research study investigates the role of information systems in enhancing end-to-end performance of rural Emergency Medical Services (EMS) systems. This study uses an embedded case study approach with multiple methods and within the context of rural Minnesota. Interviews and data analysis of the EMS process identified four elements: mayday call, routing and dispatch, response, and treatment. These data were then used to perform a preliminary simulation of rural EMS systems performance under normal and crisis conditions as a proof of concept for analyzing end-to-end performance. This process allowed for further contextual analysis of the interviews, which revealed the need for a more dynamic and comprehensive management information system as well as a forum for sharing EMS performance information across the full range of organizations involved in EMS. Constraints to enhancing EMS systems were also identified, such as a lack of funding for new technologies and an apparent disconnect between information systems coordination and service coordination. The case study reveals that while local EMS providers may have an intuitive understanding of how the entire system performs, there is a lack of systematic data to support, confirm or refute perceptions about overall performance. The paper concludes with recommendations for future related research activities.
    Type of Medium: Electronic Resource
    URL: http://www.bepress.com/jhsem/vol2/iss1/4
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    Paper (German National Licenses)
    Fulltext
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