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Digitale Medien

Some derivatives of pregna-D6′-pentaranes as possible antagonists of progesterone (1995)

Levina, I. S. ; Nikitina, G. V. ; Kulikova, L. E. ; [weitere]

Springer

Russian chemical bulletin 44 (1995), S. 547-550

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Details

ISSN: 1573-9171

Schlagwort(e): pentarane ; progestin ; Clauberg-McPhail assay ; antihormonal action ; progesterone

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie

Notizen: Abstract Some derivatives of progestins of the pregna-D6′-pentarane series have been obtained and examined for their possible hormonal and antihormonal activity in the Clauberg-McPhail assay as well as in the pregnancy maintenance test in ovariectomized rabbits. 16α, 17α-Cyclohexanoprogesterones of the 19-methyl and 19-nor series (1–4) saturated in ring A, which are inactive as progestins, exhibited a remarkable antiprogesterone effect. They decreased the McPhail index under combined administration with progesterone in a dose-dependable manner and completely inhibited the action of the latter in the pregnancy maintenance test.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00702407

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