Digitale Medien
Oxford, UK
:
Blackwell Publishing Ltd
Journal of neurochemistry
22 (1974), S. 0
ISSN:
1471-4159
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Medizin
Notizen:
Kynurenine formamidase (aryl-formylamine amidohydrolase, EC 3.5.1.9) was found to be present in rat brain and was partially purified and characterized. The partially purified enzyme catalysed the hydrolysis of 5-hydroxyformyl-dl-kynurenine to 5-hydroxy-dl-kynurenine and that of formyl-l-kynurenine to l-kynurenine at similar rates. The apparent Km values of the enzyme for 5-hydroxyformyl-dl-kynurenine and formyl-l-kynurenine were 4.0 ± 10−4 and 1.8 ± 10−4m, respectively. The enzyme was active over a wide pH range (5.5–8.5). The activity was inhibited by low concentrations of Ag+ and Hg2+. The physiological significance of the enzyme is discussed.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1111/j.1471-4159.1974.tb04280.x
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