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Digitale Medien

Decreased glycolytic flux rate in the isolated perfused rat brain after pretreatment with 6-aminonicotinamide (1975)

Krieglstein, J. ; Stock, R.

Springer

Naunyn-Schmiedeberg's archives of pharmacology 290 (1975), S. 323-327

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Details

ISSN: 1432-1912

Schlagwort(e): 6-Aminonicotinamide ; Glycolytic Pathway ; Isolated Perfused Rat Brain

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Cerebral energy metabolism was studied in the isolated perfused rat brain after 6-aminonicotinamide (6-AN; 35 mg/kg i.p.) administered to the intact animals 7 hrs before perfusion was started. The metabolic alterations in the isolated rat brains were such as reported for rat and mouse brain in vivo: Inhibition of 6-phosphogluconate dehydrogenase was followed by an accumulation of 6-phosphogluconate, leading to a decreased activity of glucosephosphate isomerase. This was reflected by increased levels of glucose and glucose 6-phosphate and decreased levels of fructose 6-phosphate, pyruvate and lactate. Since the concentration of lactate in the perfusate of the isolated brain was also lowered, 6-AN must have reduced the glycolytic flux rate.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00510561

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