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Digitale Medien

Effect of therapeutic concentrations of anthracyclines on monocyte phagocytosis of yeast cells (1989)

Athlin, L. ; Domellöf, L. ; Norberg, B.

Springer

European journal of clinical pharmacology 36 (1989), S. 155-159

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Details

ISSN: 1432-1041

Schlagwort(e): doxorubicin ; epirubicin ; monocytes ; mitoxanthrone ; phagocytosis

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary The effect of therapeutic concentrations of doxorubicin, epirubicin, and mitoxanthrone on mature leukocyte function has been examined by measuring phagocytosis of yeast cells by surface-bound monocytes, using a fluorescence-quenching method. There was a 10% inhibition of monocyte phagocytosis by doxorubicin, but epirubicin and mitoxanthrone had no effect on monocyte phagocytosis. Anthracyclines may have a major immunosuppressive effect due to bone marrow depression. The lack of interference with mature monocyte function by epirubicin and mitoxanthrone provides a potential advantage in comparison with the parent compounds.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00609188

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