ISSN:
1432-1041
Keywords:
Bioavailability
;
pharmacokinetic behaviour
;
cross-over design
;
bioequivalence
;
intra-individual differences
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The relative bioavailability of 22 registered pharmaceutical specialities compared to one or more generic equivalents was investigated in 50 human volunteers using randomized cross-over trials. The data were reassessed with regard to individual behaviour in different experiments and with different drugs. The pharmacokinetic behaviour (Cmax, Tmax, and AUCo–t) of the volunteers exhibited consistent patterns, which were not attributable to chance. It is concluded that the cross-over design is necessary in conducting relative bioavailability studies.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00541940
Permalink