ISSN:
1431-4630
Schlagwort(e):
Key words Sulphadimidine
;
Fermented sausage
;
Carbon-14-labelling
;
Rat
;
Bound residues
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
Notizen:
Abstract Sulphadimidine (SDM), a drug frequently administered to pigs, is partially converted into other compounds by processing meat to produce raw, fermented sausage. With the aid of 14C-labelled SDM, evidence was obtained that part of the radioactive matter was covalently bound to the matrix. Part of these bound residues could be released in vitro by 4 M HCl at 21 °C or by 0.024 M HCl at 37 °C. Female rats were also able to release bound SDM residues and to excrete these in their urine, in amounts approaching those obtained by treatment with 4 M HCl. Both the parent compound and its main metabolite, N 4-acetyl-SDM, were observed in the urine of rats.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/s002170050399
Permalink