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  • 1
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The influence of histamine (and the related agonists and antagonists) alone or in the presence of recombinant human interleukin 1α (IL-1α) and gamma interferon (IFN-γ) was studied on the production of complement components C3, C2, factor B, and C4 in vitro with human monocytoid cell line U937, hepatoma-derived cell line HepG2, and mouse hepatocytes. Both U937 and HepG2 cells responded to histamine through H1 and H2 histamine receptors. The effect of histamine on the biosynthesis and gene expression of complement proteins was predominantly enhancing via the H1 histamine receptors and inhibitory through the H2 receptors. The actual predominance of the histamine receptor involved (and the outcome of the ligand interaction) seemed to be greatly affected by the simultaneous activation of the cells by IL-1 or IFN-γ.
    Materialart: Digitale Medien
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  • 2
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 175 (1970), S. 0 
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
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  • 3
    Digitale Medien
    Digitale Medien
    Amsterdam : Elsevier
    International Journal of Psychophysiology 11 (1991), S. 53 
    ISSN: 0167-8760
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Medizin , Psychologie
    Materialart: Digitale Medien
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  • 4
    Digitale Medien
    Digitale Medien
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 54 (1998), S. 372-373 
    ISSN: 1600-5759
    Quelle: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Thema: Chemie und Pharmazie , Geologie und Paläontologie , Physik
    Materialart: Digitale Medien
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    Experimental brain research 95 (1993), S. 473-476 
    ISSN: 1432-1106
    Schlagwort(e): MPTP ; Paradoxical sleep ; Cat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In a previous study, we reported on a selective and long-lasting paradoxical sleep (PS) deprivation in cats following repeated administration of the Parkinson syndrome-inducing neurotoxin N-methyl-4-pheny11,2,3,6-tetrahydropyridine (MPTP). While the characteistic motor deficits occurred only from the 2nd to 3rdday of a 5-day long administration of 5 mg/kg per day MPTP i.p., the PS deprivation started immediately after the first injection and lasted altogether for 11–13 days. The motor deficiencies induced by repeated administration of MPTP are mainly due to the selective depletion of dopaminergic neurons in the nigrostriatal system as the histological and biochemical data show. The immediate onset of PS deprivation and the PS recovery, despite the definite cell loss, suggests a mechanism independent of cell destruction. In our present study we investigated the occasional histological and the PS-deprivatory effect of a single low dose of MPTP in cats. A single injection of 2 mg/kg MPTP i.p. resulted in PS deprivation lasting for 2.5–3.5 h. The duration of other sleep stages showed no significant change and PS recovery was without rebound phenomenon, as in the case of repeated administration. Even a higher single dose of MPTP (5 mg/kg) resulted in no visibly detectable nigrostriatal cell loss. We suggest that the changes in monoamine release and/or turnover are involved in the PS deprivatory effect of MPTP.
    Materialart: Digitale Medien
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  • 6
    Digitale Medien
    Digitale Medien
    Springer
    Algebra universalis 41 (1999), S. 85-86 
    ISSN: 1420-8911
    Schlagwort(e): Key words and phrases: Isotone map, countable lattice.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Materialart: Digitale Medien
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  • 7
    ISSN: 1432-2072
    Schlagwort(e): Key words Microdialysis ; Intravenous ; Psychostimulant ; Yoked ; Mesolimbic
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract   Rationale: The neurochemical effects of psychostimulant exposure may depend on how these drugs are encountered. A useful method for examining this issue is to compare neurotransmitter release following response-dependent, or self-administered, drug exposure and response-independent exposure. Objectives: This experiment examined the effect of active and passive cocaine administration on acetylcholine (ACh) efflux in the shell region of the nucleus accumbens (NAc) in rats. Methods: One group of rats (CSA: cocaine self-administration) was trained to lever-press for intravenous infusions of cocaine (0.42 mg/kg per infusion) on a fixed-ratio-1 schedule of reinforcement. Cocaine infusions were accompanied by the onset of a stimulus light that signaled a 20-s time-out period. Control rats received intravenous cocaine (cocaine non-contingent: CNC) or saline (SAL) in a manner that was not contingent upon their behavior. Drug infusions in these groups were determined by the lever-press behavior of the animals in the CSA group, i.e. they were yoked to rats in the self-administration group such that CNC animals received equal amounts of cocaine as CSA rats. Animals received cocaine or saline in 3-h sessions for 13 consecutive days before testing. On day 14, extracellular ACh was measured in 15-min intervals before, during and after a 3-h session of cocaine exposure using unilateral microdialysis probes located in the NAc shell coupled with HPLC. Results: ACh efflux was significantly increased above baseline in both groups of rats that received cocaine but CSA rats had significantly higher ACh levels during the self-administration period compared to their yoked counterparts. In addition, ACh efflux remained elevated longer in CSA animals relative to CNC rats following cessation of cocaine exposure. Conclusions: These results demonstrate that ACh interneurons in the NAc shell are responsive to cocaine exposure. In addition, these findings suggest that the manner in which the drug is administered (i.e. either by active self-administration or passive exposure) may be relevant to the magnitude of the neural response.
    Materialart: Digitale Medien
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  • 8
    Digitale Medien
    Digitale Medien
    Springer
    Graphs and combinatorics 7 (1991), S. 1-6 
    ISSN: 1435-5914
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Informatik , Mathematik
    Notizen: Abstract It is shown that any graph onn vertices containing no clique and no independent set ont + 1 vertices has at least $$2^{{n \mathord{\left/ {\vphantom {n {(2t^{20 \log (2t)} )}}} \right. \kern-\nulldelimiterspace} {(2t^{20 \log (2t)} )}}} $$ distinct induced subgraphs.
    Materialart: Digitale Medien
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  • 9
    Digitale Medien
    Digitale Medien
    Springer
    Combinatorica 13 (1993), S. 31-56 
    ISSN: 1439-6912
    Schlagwort(e): 05 C 35 ; 05 C 55
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract This paper is a continuation of [10], where P. Erdős, A. Hajnal, V. T. Sós, and E. Szemerédi investigated the following problem: Assume that a so called forbidden graphL and a functionf(n)=o(n) are fixed. What is the maximum number of edges a graphG n onn vertices can have without containingL as a subgraph, and also without having more thanf(n) independent vertices? This problem is motivated by the classical Turán and Ramsey theorems, and also by some applications of the Turán theorem to geometry, analysis (in particular, potential theory) [27–29], [11–13]. In this paper we are primarily interested in the following problem. Let (G n ) be a graph sequence whereG n hasn vertices and the edges ofG n are coloured by the colours χ1,...,χ r so that the subgraph of colour χυ contains no complete subgraphK pv , (v=1,...r). Further, assume that the size of any independent set inG n iso(n) (asn→∞). What is the maximum number of edges inG n under these conditions? One of the main results of this paper is the description of a procedure yielding relatively simple sequences of asymptotically extremal graphs for the problem. In a continuation of this paper we shall investigate the problem where instead of α(G n )=o(n) we assume the stronger condition that the maximum size of aK p -free induced subgraph ofG n iso(n).
    Materialart: Digitale Medien
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  • 10
    Digitale Medien
    Digitale Medien
    Springer
    Combinatorica 17 (1997), S. 363-367 
    ISSN: 1439-6912
    Schlagwort(e): 03E05 ; 04A20 ; 03E35
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract It is consistent that there is an order type θ for which $$\psi \not \to [\theta ]_{\aleph _1 }^2$$ holds for every type ψ.
    Materialart: Digitale Medien
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