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  • 1
    ISSN: 1432-1831
    Schlagwort(e): Key words Verocytotoxin ; Verocytotoxin-producing Escherichia coli ; Hemolytic uremic syndrome ; Renal proximal tubular cell ; Apoptosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Verocytotoxin 1 and 2 (VT1 and 2) produced by verocytotoxin-producing Escherichia coli have been considered to play an important role in the pathogenesis of glomerular and tubular damage in the epidemic form of hemolytic uremic syndrome (HUS). VTs are known to be cytotoxic to culture cells by inhibiting cellular protein synthesis. In this in vitro study, the mechanism(s) of tubular damage in HUS and the ability of VT1 to induce apoptosis in normal human renal proximal tubular epithelial cells (HRPTEC) were examined. VT1 markedly reduced cell viability of HRPTEC and rapidly inhibited overall protein synthesis. VT1 directly induced apoptotic cell death in HRPTEC in a dose- and time-dependent fashion, and co-incubation with tumor necrosis factor-α enhanced the VT1-induced apoptosis. These results suggest that apoptosis induced by VT1, possibly in concert with host cytokines, in renal tubular cells may contribute to the tubular damage in HUS.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 22 (1996), S. 43-66 
    ISSN: 0271-2091
    Schlagwort(e): multiple-level model ; finite element method ; open boundary condition ; tidal current analysis ; Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Notizen: The results of a research project to verify the newly improved multiple- level model for 3D tidal current analysis in Tokyo Bay are presented. The improved multiple-level model includes additional effects due to Coriolis force, river inflows and wind shear stresses. Furthermore, a new numerical treatment of the open boundary condition was applied which effectively eliminated the spurious reflective waves often generated by various numerical methods simulating free surface flows. The mean (time-averaged or residual) and tidal currents in Tokyo Bay were simulated as examples to demonstrate the validity and capability of the newly improved multiple-level model. A series of numerical experiments was conducted to carefully examine the tidal circulations affected by the forcing factors of Coriolis force, river inflows and wind shears, both individually and combined. The numerical results demonstrated that the effects of each forcing term are physically reasonable, with the wind shear effect being the most significant and the case including all forcing terms being in best overall agreement with the field data collected in Tokyo Bay by the Ministry of Transportation. This study has contributed not only to the verification of the newly improved multiple-level model but also to the enhancement of the accuracy of numerical simulations of three-dimensional flow in coastal waters by this model.
    Zusätzliches Material: 22 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 13 (1991), S. 939-953 
    ISSN: 0271-2091
    Schlagwort(e): Finite element method ; Shallow water equation ; Open boundary condition ; Parameter identification ; Tokyo Bay ; Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Notizen: A method to deal with an open boundary condition in the analysis of water surface waves, the tide, etc. by means of the finite element method is proposed in this paper. The present method has two important features relating to the treatment of the open boundary condition. The first feature is to consider the non-reflective virtual boundary condition which has been developed in the numerical wave analysis method. The incident wave conditions without spurious reflected waves can be imposed at the open boundary. The second feature is to identify the amplitude of the components of incident waves in terms of observed water elevations in the field of standing waves. This can be done as a parameter identification based on an optimization problem by applying the conjugate gradient method. The applicability of this method to wave propagation problems is verified by several numerical computations.
    Zusätzliches Material: 22 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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