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  • 1
    Digitale Medien
    Digitale Medien
    Marsupialization inhibits interleukin-1α expression and epithelial cell proliferation in odontogenic keratocysts (2002)
    Oxford, UK : Munksgaard International Publishers
    Journal of oral pathology & medicine 31 (2002), S. 0 
    Details
    ISSN: 1600-0714
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background:   Marsupialization results in the reduction of odontogenic cyst size. Interleukin-1α (IL-1α) is thought to play a crucial role for the expansion of odontogenic keratocysts. The aim of this study was to investigate the effects of marsupialization on the expression of IL-1α and on the proliferating activity of a lining epithelium in odontogenic keratocysts.Methods:   The concentrations of IL-1α, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in the intracystic fluids of odontogenic keratocysts were measured by the enzyme-linked immunosorbent assay (ELISA). The expression of IL-1α mRNA in odontogenic keratocysts was measured before and after marsupialization by in situ hybridization. The expression of IL-1α and epithelial cell-proliferating activities in odontogenic keratocysts were also measured by immunohistochemistry using antibodies for human IL-1α and Ki-67 antigen, respectively.Results:   The intracystic fluid levels of IL-1α were significantly higher than those of IL-6 and TNF-α in odontogenic keratocysts. In situ hybridization and immunohistochemistry showed that strong expression of IL-1α mRNA and protein was mainly detected in the epithelial cells of odontogenic keratocysts. After marsupialization, the signal intensities for IL-1α mRNA and protein were significantly decreased. In addition, the Ki-67 labeling index of the epithelial cells was decreased proportionally with the grade of IL-1α mRNA expression after the marsupialization.Conclusion:   Our findings suggest that marsupialization may reduce the size of odontogenic keratocyst by inhibiting IL-1α expression and the epithelial cell proliferation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1034/j.1600-0714.2002.00029.x
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  • 2
    Digitale Medien
    Digitale Medien
    Discrimination of ameloblastomas from odontogenic keratocysts by cytokine levels and gelatinase species of the intracystic fluids (2001)
    Copenhagen : Munksgaard International Publishers
    Journal of oral pathology & medicine 30 (2001), S. 0 
    Details
    ISSN: 1600-0714
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: In the present study, we measured the levels of the cytokines and gelatinase species in the fluids of ameloblastomas and odontogenic keratocysts, and showed that ameloblastomas can be distinguished from odontogenic keratocysts by the use of these biochemical data. We found that interleukin (IL)-1α and IL-1β levels in the intracystic fluids of ameloblastomas were significantly lower than those in the fluids of odontogenic keratocysts, while IL-6 levels in the fluids of ameloblastomas were significantly higher than those in the fluids of odontogenic keratocysts. On the other hand, no significant differences in tumor necrosis factor (TNF)-α levels of the fluids were detected between ameloblastomas and odontogenic keratocysts. An immunohistochemical study revealed that the staining intensity of IL-1α, IL-1β and TNF-α in the tumor cells of ameloblastomas was significantly weaker than that in the epithelial cells of odontogenic keratocysts, while the staining intensity of IL-6 in the tumor cells was significantly stronger than that in the epithelial cells of odontogenic keratocysts. Gelatin zymography of the fluids showed that only a small amount of pro-MMP-9 was detected in ameloblastomas, while both pro-MMP-9 and the active form of MMP-9 were detected in 8 of 10 cases of odontogenic keratocysts. Thus, ameloblastomas can be distinguished from odontogenic keratocysts by measuring IL-1α and IL-6 levels, and gelatinase species in the fluids.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1034/j.1600-0714.2001.300707.x
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  • 3
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    Unbekannt
    DOKO TOSHIO (1979)
    Tokyo : Periodicals Archive Online (PAO)
    Japan Quarterly. 26:4 (1979:Oct./Dec.) 500 
    Details
    ISSN: 0021-4590
    Thema: Sociologie , Wirtschaftswissenschaften
    Notizen: PEOPLE IN THE SPOTLIGHT
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:6125-1979-026-04-000011
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