ISSN:
1432-0568
Schlagwort(e):
Key words Brainstem
;
Horseradish peroxidase
;
Nerve injury
;
Sprouting
;
Regeneration
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract In order to investigate the changes in the somatosensory organization that occur after a peripheral nerve injury, a purely sensory nerve (radial nerve – superficial branch) was divided in adult monkeys (Macaca fascicularis). The nerve ends were immediately rejoined by an epineural suturing technique. After 6–21 months the nerve investigated was exposed to an intra-axonal nerve tracer (horseradish peroxidase conjugate) in order to label the primary afferent terminals within the cuneate nucleus of the brainstem. The non-transected nerve on the contralateral side was similarly exposed and served as a control. Terminal labelling was seen throughout the cuneate nucleus, mainly in the middle of its rostro-caudal extension, and in this part it showed a patchy appearance superimposed on cell clusters within the pars rotunda. This pattern of distribution was seen both on the experimental and control sides. On the experimental side there was an obvious loss of terminal labelling within the terminal field as estimated using an image-analysing system: Compared with the contralateral side the median loss (peroxidase activity) was 83% and between 6 and 21 months only minor restoration of the terminal intensity was observed. These results in the primate confirm earlier results in the cat that transection and microsurgical repair of a sensory nerve causes a considerable loss of neurons capable of intraaxonal transport.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/s004290050097
Permalink
