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  • 1
    Digitale Medien
    Digitale Medien
    5-HT3 receptor over-expression decreases ethanol self administration in transgenic mice (1998)
    Springer
    Psychopharmacology 140 (1998), S. 243-248 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Key words 5-HT3 receptor ; Over-expression ; Transgenic animal model ; Alcohol drinking
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  The 5-HT3 receptor is thought to play a role in the reward pathway and the phenomena of drug abuse by modulating dopamine release in the mesolimbic pathway. Studies involving this receptor have been hampered due to the low level of 5-HT3 receptors in the CNS. A 5-HT3 receptor over-expressing mouse was produced to study the role of this receptor in the rewarding properties of drugs of abuse. Over-expression was restricted to the forebrain by controlling gene expression with the Ca2+ calmodulin (CAM) kinase IIα promoter. No over-expression was detected in other body organs nor the cerebellum, as measured by ligand binding and Northern analysis. 5-HT3 receptor over-expressing mice drank less alcohol than non-transgenic mice in a two-bottle free choice test. Over-expression of the 5-HT3 receptor in these mice resulted in a decrease in ethanol consumption. These mice should prove useful in testing hypothesis regarding a common reward pathway for drugs of abuse and the role 5-HT3 receptors play in this pathway.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002130050763
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Preparation of ultrathin reverse osmosis membranes and the attainment of theoretical salt rejection (1967)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 11 (1967), S. 2143-2158 
    Details
    ISSN: 0021-8995
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Maschinenbau , Physik
    Notizen: Cellulose acetate reverse osmosis membranes, 600-2800 A. thick, have been prepared on glass surfaces by dipping a clean glass plate into a dilute solution of cellulose acetate. After drying, the membranes are floated of onto a water surface and placed on molecular filter supports. Theoretical salt rejections, as calculated from the solution-diffusion model of membrane transport for cellulose acetate, were obtained with imperfection-free membranes.
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/app.1967.070111106
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Composite membranes for seawater desalination by reverse osmosis (1971)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 15 (1971), S. 1267-1276 
    Details
    ISSN: 0021-8995
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Maschinenbau , Physik
    Notizen: A composite reverse-osmosis membrane has been developed for seawater desalination having a 400-Å semipermeable barrier. The membrane is prepared by directly forming a very thin film of a polymer, generally cellulose triacetate, upon the finely porous surface of a supporting membrane. The composite membrane, capable of desalinating seawater in a single pass, has demonstrated improved flux stability at high pressures over modified membranes currently used to desalinate brackish water.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/app.1971.070150520
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