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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Digestive diseases and sciences 45 (2000), S. 129-135 
    ISSN: 1573-2568
    Schlagwort(e): duodenum ; distension ; intestinal motility ; intestinal pacing ; electrical stimulation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The aims of this study were to investigate the effect of duodenal distension on intestinal myoelectrical activity and to investigate whether intestinal pacing was able to reverse the effects of distension. Six female hound dogs with four pairs of electrodes on the proximal jejunum were involved in this study. The protocol consisted of 30 min of recording of jejunal myoelectrical activity as baseline and 90 min of recording during distension. Intestinal pacing was performed during the second 30 min of distension. Duodenal distension severely impaired intestinal myoelectrical activity. The percentage of normal slow waves was reduced from 90.8 ± 8.4% at baseline to 73.8 ± 10.2%, 57.2 ± 11.4%, and 53.7 ± 16.0% during the first, second and third 30 min of distension (P 〈 0.05, ANOVA). The dominant power was similarly decreased and the minute-by-minute variation of dominant frequency was significantly increased after distension. Intestinal pacing reversed distension-induced dysrhythmia. The percentage of normal slow waves during the 30 min of distension with pacing was significantly higher than the corresponding 30 min of distension without pacing (88.5 ± 6.6% vs 57.2 ± 11.4%, P 〈 0.03). It was concluded that intestinal pacing can normalize distension-induced dysrhythmia and has a potential as a future therapeutic modality for intestinal motor disorders.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Digestive diseases and sciences 44 (1999), S. 56-62 
    ISSN: 1573-2568
    Schlagwort(e): GASTRIC SLOW WAVES ; GASTRIC MOTILITY ; GASTRIC EMPTYING ; ELECTROACUPUNCTURE ; ELECTROGASTROGRAPHY
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The aim of this study was to investigate thecharacteristics of the gastric slow wave duringdifferent phases of the migrating myoelectrical complex(MMC) and the effect of electroacupuncture on the MMC. The experiment was performed in eight hounddogs implanted with one pair of bipolar serosalelectrodes 2 cm proximal to the pylorus. Gastricmyoelectrical activity was recorded for three completecycles of the MMC in two sessions, one withelectroacupuncture at points ST36 and PC6 and the otherat sham points. The acupuncture was performed for 30 minin phase I of the second cycle of the MMC. Spectral analysis was performed to compute the frequencyand power (amplitude) of the gastric slow wave, whereasblind visual analysis was applied to compute theappearance of spike potentials and the length of each phase of the MMC. It was found that therewas a significant difference in the frequency and powerof the gastric slow wave during different phases of theMMC (P 〈 0.05). Phase I was characterized with the highest frequency and lowest power ofthe gastric slow wave, whereas phase III exhibited thehighest power in the slow wave. It was also found thatin comparison with the sham points, electroacupuncture at the acupoints increased the number of spikebursts. This increase was not significant during the MMCcycle with electroacupuncture (34.4 ± 4.1 vs 27.5± 2.5%, P 〉 0.05) but became significant during the cycle after electroacupuncture (39.8± 3.3% vs 27.5 ± 2.5%, P 〈 0.0005).Similarly, during the MMC cycle after electroacupunctureat the acupoints, there was a significant decrease in the length of phase I (14.8 ± 2.2 vs46.9 ± 6.1 min, P 〈 0.003) and a significantincrease in the length of phase II (75.6 ± 9.9 vs30.6 ± 4.1 min, P 〈 0.003) and phase III (25.8± 0.6 vs 22.1 ± 0.7 min, P 〈 0.003). A similarincrease was observed during the MMC cycle withelectroacupuncture but was not statisticallysignificant. In conclusion, the gastric slow wave hasthe highest power during phase III of the MMC, indicatingthat the antral contraction is characterized not only bythe appearance of spikes, but also by the increasedpower of the slow wave. Electroacupuncture at acupoints of ST36 and PC6 enhances the gastric MMC byreducing the length of phase I and increasing the lengthof phases II and III.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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