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  • 1
    Digitale Medien
    Digitale Medien
    Synthesis and Rates of Acetolysis of exo-exo and exo-endo-Tricyclo[3.2.1.02,4]octan-6-yl p-Bromobenzenesulfonates1,2 (1965)
    s.l. : American Chemical Society
    The @journal of organic chemistry 30 (1965), S. 2462-2464 
    Details
    ISSN: 1520-6904
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/jo01018a509
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  • 2
    Digitale Medien
    Digitale Medien
    Diminished Akt phosphorylation in neurons lacking glutathione peroxidase-1 (Gpx1) leads to increased susceptibility to oxidative stress-induced cell death (2005)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 92 (2005), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: We have previously identified an increased susceptibility of glutathione peroxidase-1 (Gpx1)–/– mice to neuronal apoptosis following mid-cerebral artery (MCA) occlusion. This study was designed to elucidate the mechanisms involved in elevated neuronal cell death arising from an altered endogenous oxidant state. This was addressed in both an in vitro and in vivo model of oxidative stress in the form of exogenous H2O2 and cerebral ischaemia, respectively. Increased levels of cell death were detected in primary neurons lacking Gpx1 following the addition of exogenous H2O2. This increased apoptosis correlated with a down-regulation in the activation of the phospho-inositide 3-kinase [PI(3)K]–Akt survival pathway. The importance of this pathway in protecting against H2O2-induced cell death was highlighted by the increased susceptibility of wildtype neurons to apoptosis when treated with the PI(3)K inhibitor, LY294002. The Gpx1–/– mice also demonstrated elevated neuronal cell death following MCA occlusion. Although Akt phosphorylation was detected in the Gpx1–/– brains, activation was not seen in later reperfusion events, as demonstrated in wildtype brains. Previous studies have highlighted the importance of Akt phosphorylation in protecting against neuronal cell death following cerebral ischaemia–reperfusion. Our results suggest that the increased susceptibility of Gpx1–/– neurons to H2O2-induced apoptosis and neuronal cell death in vivo following cerebral ischaemia–reperfusion injury can be attributed in part to diminished activation of Akt. Perturbations in key anti-apoptotic mechanisms as a result of an altered redox state may have implications in the study of oxidative stress-mediated neuropathologies.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.2004.02863.x
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  • 3
    Digitale Medien
    Digitale Medien
    Perioperative management of face-to-face craniopagus twins separation (2005)
    Oxford, UK : Blackwell Science Ltd
    Pediatric anesthesia 15 (2005), S. 0 
    Details
    ISSN: 1460-9592
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Craniopagus conjoining represents a complex and challenging issue for neurosurgeons as well as for anesthesiologists. A rare face-to-face case of conjoined twins underwent surgical separation and presented peculiar differences compared with those already reported in the literature. Even in cases lacking large cerebrovascular sinus connections, the impending risk of large blood loss and hemorrhagic shock in the infant requires a high level of surveillance and the institution of invasive monitoring.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1460-9592.2004.01480.x
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  • 4
    Digitale Medien
    Digitale Medien
    Three further dolabellane diterpenoids from Dictyota sp.
    Amsterdam : Elsevier
    Phytochemistry 23 (1984), S. 1681-1684 
    Details
    ISSN: 0031-9422
    Schlagwort(e): Dictyota ; Phaeophyceae ; brown alga ; diterpenes ; dolabellane derivatives.
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0031-9422(00)83468-8
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  • 5
    Digitale Medien
    Digitale Medien
    Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury (2001)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 78 (2001), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Glutathione peroxidase is an antioxidant enzyme that is involved in the control of cellular oxidative state. Recently, unregulated oxidative state has been implicated as detrimental to neural cell viability and involved in both acute and chronic neurodegeneration. In this study we have addressed the importance of a functional glutathione peroxidase in a mouse ischemia/reperfusion model. Two hours of focal cerebral ischemia followed by 24 h of reperfusion was induced via the intraluminal suture method. Infarct volume was increased three-fold in the glutathione peroxidase-1 (Gpx-1) –/– mouse compared with the wild-type mouse; this was mirrored by an increase in the level of apoptosis found at 24 h in the Gpx-1 –/– mouse compared with the wild-type mouse. Neuronal deficit scores correlated to the histologic data. We also found that activated caspase-3 expression is present at an earlier time point in the Gpx-1 –/– mice when compared with the wild-type mice, which suggests an enhanced susceptibility to apoptosis in the Gpx-1 –/– mouse. This is the first known report of such a dramatic increase, both temporally and in level of apoptosis in a mouse stroke model. Our results suggest that Gpx-1 plays an important regulatory role in the protection of neural cells in response to the extreme oxidative stress that is released during ischemia/reperfusion injury.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1471-4159.2001.00535.x
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  • 6
    Digitale Medien
    Digitale Medien
    Hemimegalencephaly associated with somatic hemihypertrophy and a malformation of the feet: case report (1996)
    Springer
    Neuroradiology 38 (1996), S. 367-370 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Hemimegalencephaly ; Congenital cerebral malformations ; Neuronal migration anomalies
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Hemimegalencephaly (HME) is a rare neuronal migration anomaly, rarely associated with hemihypertrophy or some other somatic malformation; it can coexist with intracranial arteriovenous shunts which cause cardiac failure. We report a rare case associated with hemihypertrophy of the face, trunk and limbs and malformation of the feet. The neuroradiological findings are underlined and the differential diagnoses discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00596590
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  • 7
    Digitale Medien
    Digitale Medien
    A practical approach to the phlebographic study of the lateral cerebral ventricles (1975)
    Springer
    Neuroradiology 10 (1975), S. 111-119 
    Details
    ISSN: 1432-1920
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Résumé Les auteurs décrivent les aspects anatomiques principaux des veines épendymaires des ventricules latéraux. Ils soulignent l'importance de ces veines dans l'étude de la forme et des dimensions des ventricules latéraux, les modifications les plus typiques des veines épendymaires en cas d'hydrocéphalie ou de tumeurs cérébrales. Ils indiquent le moyen d'identification des veines latérales et médianes de chaque segment ventriculaire. Cela est possible grâce à l'étude phlébographique dans les projections orthogonales.
    Kurzfassung: Zusammenfassung Die Autoren beschreiben die bedeutendsten anatomischen Aspekte der subependymalen Venen der Seitenventrikel. Sie unterstreichen die Bedeutung der subependymalen Venen in der Bestimmung der Form und Größe der Seitenventrikel. Die bedeutendsten Variationsmöglichkeiten im Falle von Veränderungen in Größe und Form der Ventrikel als Nachweis von raumfordernden intrakraniellen Prozessen werden aufgeführt. Die Autoren unterstreichen weiterhin die Bedeutung der Faktoren, die zum exakten Nachweis der seitlichen und medialen Venen jedes Ventrikelteiles dienen. Dies ist möglich dank der phlebographischen Untersuchungen in den senkrechten Projektionen.
    Notizen: Summary The main anatomical features of the subependymal veins of the lateral ventricles are summarized. The important role of the subependymal veins for the study of the size and shape of the lateral ventricles is outlined. The most typical modifications which occur in cases of ventricular enlargement or ventricular deformation due to cerebral tumors are illustrated. The importance of the criteria to be followed for the exact identification of the lateral and medial veins of each ventricular portion are stressed. This is possible thanks to the combined study of the phlebograms in the right angled projections.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00338555
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  • 8
    Digitale Medien
    Digitale Medien
    Dandy-Walker syndrome: Diagnosis in utero by means of ultrasound and CT correlations (1983)
    Springer
    Neuroradiology 24 (1983), S. 233-235 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Dandy-Walker syndrome ; Hydrocephalus ; Posterior fossa cyst ; Brain, ultrasound
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A case of Dandy-Walker syndrome was diagnosed by ultrasound during the 30th week of pregnancy, observed again more clearly at 33 weeks and confirmed by CT after birth.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00399778
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  • 9
    Digitale Medien
    Digitale Medien
    Normal limits of the lateral cerebral ventricles on the lateral phlebogram: A statistical analysis (1977)
    Springer
    Neuroradiology 13 (1977), S. 255-258 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Lateral cerebral ventricles ; Subependymal veins ; Ventricular deformity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The highest points of the subependymal veins of the lateral cerebral ventricles (frontal horn, body and atrium) and the height of the body have been evaluated in selected patients. Through a statistical analysis, they have been demonstrated to depend on the height of the supratentorial compartment of the skull. Taking into account this relation, the results obtained furnish reliable criteria for evaluating ventricular enlargement or sectional deformity.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00347068
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  • 10
    Digitale Medien
    Digitale Medien
    The value of CT for the diagnosis of pituitary microadenomas in children (1978)
    Springer
    Neuroradiology 15 (1978), S. 179-181 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Prepuberal pituitary dwarfism ; Pituitary microadenomas ; CT scan ; Transphenoid surgery ; Sella turcica
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Three cases of prepuberal hypopituitary dwarfism regarded as idiopathic, are reported. In two of them the skull X-rays showed questionable minimal alterations of the sella turcica; in the remaining child the examination was completely negative. All three children were found to have a pituitary intrasellar microadenoma on the CT scan. The diagnosis was confirmed during surgery. The postoperative followup demonstrated the relation of the lesion with growth retardation and the indication for surgical treatment.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00329065
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