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  • 1
    Digitale Medien
    Digitale Medien
    Plasmacytoid myoepithelioma of the palate (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 10 (1981), S. 0 
    Details
    ISSN: 1600-0714
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: We present the second case of plasmacytoid myoepithelioma of the palate, which was studied by light and electron microscopy. Apart from plasmacytoid cells, some spindle-shaped cells were also observed. Both types of neoplastic cells had myoepithelial features, showing abundant 50–80 A thick filaments in the cytoplasm, and exhibited desmosomal junctions. A few light cells with less abundant filaments and better equipped with other organelles were observed.Our findings show that there is no clear-cut distinction between the so-called plasmacytoid myoepithelioma and the spindle and stellate myoepithelioma. We suggest that the ultrastructural appearance of these tumors together with the usual histological criteria for malignancy may be used to evaluate their prognosis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0714.1981.tb01243.x
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  • 2
    Digitale Medien
    Digitale Medien
    Letters to the editor (1993)
    Springer
    World journal of surgery 17 (1993), S. 417-418 
    Details
    ISSN: 1432-2323
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01658717
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  • 3
    Digitale Medien
    Digitale Medien
    Mucins and mucin-associated carbohydrate antigens expression in gastric carcinoma cell lines (1999)
    Springer
    Virchows Archiv 435 (1999), S. 479-485 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Key words Mucins ; MUC1 ; MUC5AC ; MUC6 ; Gastric carcinoma cell lines
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  Mucins are high-molecular-mass glycoproteins with high carbohydrate content and marked heterogeneity both in the apoprotein and in the oligosaccharide side chains. Mucin genes are expressed in a regulated manner, namely in the human stomach. The first aim of the present study was to characterise the expression of mucins and mucin-associated carbohydrate antigens in seven gastric carcinoma cell lines, and to compare their expression profiles with those of normal gastric tissues and human gastric carcinomas. Secondly, we aimed to see whether or not there is an association between the expression of mucins and mucin-associated carbohydrate antigens. Our results show that mucin expression in gastric carcinoma cell lines: (a) follows in part the mucin expression profile of normal gastric mucosa and gastric carcinomas with wide expression of MUC1 and MUC5AC; (b) parallels the aberrant pattern of mucin expression observed in human gastric carcinomas with occasional expression of MUC2, MUC3, MUC4 and MUC5B; (c) does not include, at least in our series, the expression of MUC6 mucin; and (d) follows in part the differentiation pattern of the carcinomas from which the cell lines originated, keeping S-Tn expression in cell lines derived from glandular carcinomas. Our results further demonstrate that there is no apparent relationship between the mucin core proteins and the simple mucin-type or Lewis carbohydrate antigens.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004280050431
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  • 4
    Digitale Medien
    Digitale Medien
    Ultrastructural and electron immunohistochemical features of medullary thyroid carcinoma (1989)
    Springer
    Virchows Archiv 414 (1989), S. 375-384 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Thyroid neoplasms ; Electron microscopy ; Immunohistochemistry ; Calcitonin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary An ultrastructural study, both morphological and immunohistochemical, has been carried out on eight thyroglobulin-positive and nine thyroglobulin-negative medullary carcinomas of the thyroid. The morphometric analysis of granule size showed that all tumours contained cells with small granules and cells with medium size granules, whereas eight tumours had additional cells with large granules. The small granules had an electron dense core, while the medium and large sized granules were both pale-cored and dense-cored. The cells with small, medium or large secretory granules were all immunoreactive for calcitonin and CGRP. No ultrastructural differences were observed between thyroglobulin-positive and thyroglobulin-negative cases of medullary carcinoma of the thyroid.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00718620
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  • 5
    Digitale Medien
    Digitale Medien
    Solitary fibrous tumour of the thyroid: Clinicopathological, immunohistochemical and ultrastructural study of three cases (1993)
    Springer
    Virchows Archiv 422 (1993), S. 491-497 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Solitary fibrous tumour ; Mesenchymal tumour ; Thyroid ; Immunohistochemistry ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We describe three cases of solitary fibrous tumour (SFT) arising from thyroid stroma. Grossly, the tumours were clearly delimited but only partly encapsulated. The following histomorphological growth patterns were observed: bundles of cells in storiform configuration; non-structured bundles; prevalence of fibrous matrix; highly cellular, non-structured; prevalence of loose, non-structured extracellular substance; cellular proliferation and vascular spaces in a haemangiopericytic configuration and a lipomatous component. Immunohistochemical investigation demonstrated intense, diffuse vimentin positivity and focal, less intense actin positivity in all three cases. At electron microscopy we observed a primitive cell of mesenchymal type, with cytoplasm poor in organelles and rich in filaments; this cell sometimes presented differentiation characteristics. SFT is at present the most correct term for the lesions presented here despite some morphological characteristics which differ from cases reported in the literature.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01606459
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  • 6
    Digitale Medien
    Digitale Medien
    Pattern of expression of intermediate cytokeratin filaments in the thyroid gland: an immunohistochemical study of simple and stratified epithelial-type cytokeratins (1997)
    Springer
    Virchows Archiv 430 (1997), S. 239-245 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Papillary carcinoma ; Follicular carcinoma ; Immunohistochemistry ; Cytokeratin filaments
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The expression of simple and stratified epithelial-type cytokeratin (CK) intermediate filaments was evaluated by immunohistochemistry in a series of 41 papillary carcinomas, 10 follicular carcinomas, 2 poorly differentiated carcinomas and 34 specimens of normal thyroid parenchyma and lymphocytic thyroiditis. The aim of the study was to establish the CK profile of normal thyroid and thyroid carcinomas in order to clarify the putative application of CK immunostaining in diagnostic surgical pathology, and to evaluate whether the process of neoplastic transformation and tumour progression in the thyroid may be associated with any particular change in CK expression. Normal thyroid strongly expressed simple epithelial-type CKs 7 and 18 and, to a lesser degree, CKs 8 and 19, but did not express stratified epithelial-type CKs. The same pattern was found in lymphocytic thyroiditis, though the CK 19 immunoreactivity was stronger in these lesions than in the normal thyroid. Papillary and follicular thyroid carcinomas shared the expression of simple epithelial-type CKs 7, 8, 18 and 19. Immunoreactivity for CK 19 was frequently stronger and more widely distributed within each particular tumour in papillary than in follicular carcinomas, but it could also be detected, at least focally, in every follicular carcinoma. Strong expression of CK 19 highlighted small foci of papillary carcinoma not easily identifiable by conventional histological examination. Stratified epithelial-type CKs 5/6 and 13 were detected in a high percentage of papillary carcinomas, in contrast to their absence in follicular carcinomas and normal thyroid. The CK pattern was similar in primary and metastatic papillary carcinomas. We conclude that papillary carcinoma of the thyroid presents a distinct CK profile that may be used for diagnostic purposes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01324808
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  • 7
    Digitale Medien
    Digitale Medien
    Prognosefaktoren bei differenzierten Schilddrüsenkarzinomen (1997)
    Springer
    Der Pathologe 18 (1997), S. 275-285 
    Details
    ISSN: 1432-1963
    Schlagwort(e): Schlüsselwörter Schilddrüse ; Karzinome ; Prognose ; Pathologie ; Histologie ; Key words Thyroid ; Carcinoma ; Prognosis ; Pathology ; Histology
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Summary This review aims at describing the influence of established and not yet sufficiently characterized parameters on the prognosis of thyroid follicle cell carcinomas. The analysis of literature data covers a broad spectrum of pathologic and biologic factors from classical prognostic features like age, gender and tumor stage to mutation, activation or, where applicable, inactivation of tumor suppressor genes, metastasis-related genes and adhesion molecules.
    Notizen: Zusammenfassung Der Einfluß etablierter und noch nicht abschließend beurteilbarer Parameter auf die Prognose von Follikelzellkarzinomen der Schilddrüse wird dargestellt. Das Spektrum der in dieser umfangreichen Literaturanalyse enthaltenen pathologischen und biologischen Faktoren reicht von klassischen Prognosemerkmalen wie Alter, Geschlecht und Tumorstadium bis hin zur Mutation bzw. Aktivierung oder Inaktivierung von Tumorsuppressor-Genen, Metastasierungs-assoziierten Genen und Adhäsionsmolekülen.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002920050217
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