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Digitale Medien

Characterization by T1-oligonucleotide fingerprinting of three strains of human hepatitis A virus isolated in Italy (1990)

Fiore, L. ; Paolis, E. ; Novello, F. ; [weitere]

Springer

European journal of epidemiology 6 (1990), S. 29-33

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Details

ISSN: 1573-7284

Schlagwort(e): Human hepatitis A virus ; T1oligonucleotide fingerprinting ; Genomic stability

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Three human hepatitis A virus strains, all of them isolated in Italy but one acquired abroad, were analyzed by T1 - RNAase oligonucleotide mapping and by monoclonal antibody neutralization. The variation among their genomes according to T1 - maps was calculated to be about 9%, thus confirming the poor genomic variation assessed by nucleotide sequencing (1 – 10%). However T1 - maps of these Italian isolates were different from those reported in the literature (Weitz and Siegl, 1985). Neutralization by monoclonal antibody caused a reduction in titres of 2 – 2.5 log10. This genomic stability, if confirmed, is important with a view to a valuable vaccine.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00155545

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