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Digitale Medien

Effect of recombinant human granulocyte colony-stimulating factor on human neutrophil adherence in vitro (1990)

Okada, Y. ; Kawagishi, M. ; Kusaka, M.

Springer

Cellular and molecular life sciences 46 (1990), S. 1050-1053

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Details

ISSN: 1420-9071

Schlagwort(e): Recombinant human G-CSF ; neutrophil ; adherence ; dacron

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Summary We measured the effects of recombinant human granulocyte-colony stimulating factor (rhG-CSF) on the adherence of human neutrophils by using a dacron fiber system to assay the adhesive ability of neutrophils. rhG-CSF enhanced neutrophil adherence to dacron fibers. N-formyl-methionyl-leucyl-phenylalanine (fMLP) induced neutrophil-neutrophil interaction (neutrophil aggregation) in addition to neutrophil-dacron interaction, whereas rhG-CSF did not cause neutrophil aggregation. These results indicated that rhG-CSF increases the adhesive ability of neutrophils without neutrophil-neutrophil interaction, and the action of rhG-CSF in neutrophil activation is different from the neutrophil activation caused by fMLP.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01940670

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