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Digitale Medien

Degeneration of retinal neuroblasts by chinoform-ferric chelate (1982)

Ohtsuka, K. ; Ohishi, N. ; Eguchi, G. ; [weitere]

Springer

Cellular and molecular life sciences 38 (1982), S. 120-122

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ISSN: 1420-9071

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Summary The possible mechanism of neuropathic effect of chinoform was investigated using cultured retinal neuroblasts from chick embryos. Retinal neuroblasts completely degenerated by chinoform-ferric chelate within a day. This change, however, was not observed with free chinoform or ferric ion.a-Tocopherol had a potent protective effect on the toxicity of the chelate. From these results, it was concluded that the lipid peroxidation due to ferric ion chelated with chinoform incorporated into the membrane of nerve tissues is the most important step in induction of the neuropathy.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01944564

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