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Digitale Medien

Increased 1,25-dihydroxyvitamin D3 synthesis in rats fed a high-phosphorus diet (1981)

Siu, G. M. ; Draper, H. H.

Springer

Calcified tissue international 33 (1981), S. 667-672

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Details

ISSN: 1432-0827

Schlagwort(e): 1,25-Dihydroxyvitamin D3 ; Hypocalcemia ; Hyperphosphatemia

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin , Physik

Notizen: Summary Rats fed vitamin D-deficient diets containing 0.6% Ca and 0.3%, 0.6%, 1.2%, or 1.8% P exhibited progressive increments of hypocalcemia and hyperphosphatemia. In vitro assay of 25-hydroxyvitamin D3-1-α-hydroxylase (1-α-hydroxylase) activity in isolated kidney cortical mitochondria showed that hyperphosphatemia in the presence of hypocalcemia was associated with an increase in enzyme activity. The results indicate that the stimulation of 1-α-hydroxylase associated with depressed plasma Ca in rats fed a high-P diet overrides any inhibition of the enzyme that may be caused by excess plasma phosphate.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF02409506

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